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Serum Carcinoembryonic Antigen Correlates With Severity Of Idiopathic Pulmonary Fibrosis.
MedLine Citation:
PMID:  22816375     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
SUMMARY AT A GLANCE: This study demonstrates that serum carcinoembryonic antigen is increased in IPF and has a significant negative correlation with lung function. Moreover, a potential mechanism of this tumor antigen elevation has been suggested by demonstration of immunohistochemical evidence of CEA staining by metaplastic alveolar epithelium lining the honeycomb cysts and respiratory bronchioles. ABSTRACT: Background and Objective:  Idiopathic pulmonary fibrosis (IPF) is the commonest idiopathic interstitial pneumonia and carries a poor prognosis. Epidemiological evidence suggests that patients with IPF have an increased risk of developing lung cancer. Carcinoembryonic antigen (CEA) has a close association with epithelial malignancy. The aim of this study was to evaluate serum CEA concentrations in patients with IPF and to perform correlation with pulmonary function. Methods:  In a prospective study serum CEA concentrations were measured by 2-site sequential chemiluminescent immunometric assay in 41 non-smoking patients with IPF. Patients with a history of gastrointestinal tract malignancy or other disorder known to be associated with raised serum CEA were excluded. Results:  A total of 41 patients were evaluated. The mean (±SD) age of patients was 73±7 years. The mean (±SD) forced vital capacity (FVC) was 88±20% of predicted, and the mean (±SD) diffusing factor for carbon monoxide (DLco) was 52±19% of predicted. Twenty one (51%) patients had a serum CEA concentration higher than upper limit of the normal range (0-5 ng/ml). CEA concentration was significantly negatively correlated with lung function (P=0.005; R(2) =0.20 for FVC and P=0.006; R(2) =0.20 for DLco). Raised CEA level also correlated significantly with the extent of fibrosis. A lung biopsy specimen from a patient with IPF demonstrated strong staining for CEA in metaplastic epithelium lining the honeycombed cysts and respiratory bronchioles, whereas normal lung tissue was negative. Conclusions:  Serum CEA concentration is elevated in approximately half of patients with IPF and is correlated with disease severity. Immunohistochemical staining reveals that CEA localizes to metaplastic epithelium lining honeycombed bronchioles. © 2012 The Authors. Respirology © 2012 Asian Pacific Society of Respirology.
Authors:
Ahmed Fahim; Michael G Crooks; Rachel Wilmot; Anne P Campbell; Alyn H Morice; Simon P Hart
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-7-23
Journal Detail:
Title:  Respirology (Carlton, Vic.)     Volume:  -     ISSN:  1440-1843     ISO Abbreviation:  -     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-7-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9616368     Medline TA:  Respirology     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 The Authors. Respirology © 2012 Asian Pacific Society of Respirology.
Affiliation:
Division of Cardiovascular and Respiratory Studies, University of Hull, Castle Hill Hospital, Castle Road, Cottingham, UK Hull and East Yorkshire Hospitals Trust, Hull Royal Infirmary, Hull HU3 2JZ UK.
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