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Serum Carcinoembryonic Antigen Correlates With Severity Of Idiopathic Pulmonary Fibrosis.
MedLine Citation:
PMID:  22816375     Owner:  NLM     Status:  Publisher    
SUMMARY AT A GLANCE: This study demonstrates that serum carcinoembryonic antigen is increased in IPF and has a significant negative correlation with lung function. Moreover, a potential mechanism of this tumor antigen elevation has been suggested by demonstration of immunohistochemical evidence of CEA staining by metaplastic alveolar epithelium lining the honeycomb cysts and respiratory bronchioles. ABSTRACT: Background and Objective:  Idiopathic pulmonary fibrosis (IPF) is the commonest idiopathic interstitial pneumonia and carries a poor prognosis. Epidemiological evidence suggests that patients with IPF have an increased risk of developing lung cancer. Carcinoembryonic antigen (CEA) has a close association with epithelial malignancy. The aim of this study was to evaluate serum CEA concentrations in patients with IPF and to perform correlation with pulmonary function. Methods:  In a prospective study serum CEA concentrations were measured by 2-site sequential chemiluminescent immunometric assay in 41 non-smoking patients with IPF. Patients with a history of gastrointestinal tract malignancy or other disorder known to be associated with raised serum CEA were excluded. Results:  A total of 41 patients were evaluated. The mean (±SD) age of patients was 73±7 years. The mean (±SD) forced vital capacity (FVC) was 88±20% of predicted, and the mean (±SD) diffusing factor for carbon monoxide (DLco) was 52±19% of predicted. Twenty one (51%) patients had a serum CEA concentration higher than upper limit of the normal range (0-5 ng/ml). CEA concentration was significantly negatively correlated with lung function (P=0.005; R(2) =0.20 for FVC and P=0.006; R(2) =0.20 for DLco). Raised CEA level also correlated significantly with the extent of fibrosis. A lung biopsy specimen from a patient with IPF demonstrated strong staining for CEA in metaplastic epithelium lining the honeycombed cysts and respiratory bronchioles, whereas normal lung tissue was negative. Conclusions:  Serum CEA concentration is elevated in approximately half of patients with IPF and is correlated with disease severity. Immunohistochemical staining reveals that CEA localizes to metaplastic epithelium lining honeycombed bronchioles. © 2012 The Authors. Respirology © 2012 Asian Pacific Society of Respirology.
Ahmed Fahim; Michael G Crooks; Rachel Wilmot; Anne P Campbell; Alyn H Morice; Simon P Hart
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-7-23
Journal Detail:
Title:  Respirology (Carlton, Vic.)     Volume:  -     ISSN:  1440-1843     ISO Abbreviation:  -     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-7-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9616368     Medline TA:  Respirology     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 The Authors. Respirology © 2012 Asian Pacific Society of Respirology.
Division of Cardiovascular and Respiratory Studies, University of Hull, Castle Hill Hospital, Castle Road, Cottingham, UK Hull and East Yorkshire Hospitals Trust, Hull Royal Infirmary, Hull HU3 2JZ UK.
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