Document Detail

Serum CPK isoenzyme BB as an indicator of brain tissue damage following head injury.
MedLine Citation:
PMID:  7206005     Owner:  NLM     Status:  MEDLINE    
In a study of 209 patients who had serum drawn for assay of creatine phosphokinase (CPK) isoenzymes, an attempt was made to correlate elevation of CPK brain fraction (BB) with occurrence of brain injury and to evaluate its sensitivity as an indicator of the presence of brain damage. Thirty-three patients had suffered serious head trauma. However, of the ten patients in coma, only three had elevated serum CPK-BB levels. Twenty-four of the other 176 patients who had no history and head injury also had positive BB fractions. Serum CPK-BB level was therefore an unreliable indicator of the extent of brain damage.
R R Karpman; P R Weinstein; P R Finley; B Karst-Sabin
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of trauma     Volume:  21     ISSN:  0022-5282     ISO Abbreviation:  J Trauma     Publication Date:  1981 Feb 
Date Detail:
Created Date:  1981-05-21     Completed Date:  1981-05-21     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0376373     Medline TA:  J Trauma     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  148-51     Citation Subset:  AIM; IM    
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MeSH Terms
Brain Injuries / blood,  diagnosis*
Child, Preschool
Coma / blood
Creatine Kinase / blood*
Middle Aged
Neurologic Examination
Reg. No./Substance:
0/Isoenzymes; EC Kinase

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