| Serum C3 content in vitamin B(12)-deficient rats. | |
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MedLine Citation:
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PMID: 9565823 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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As a clue to clarifying the role of vitamin B12 (B12) in the function of the complement system, serum C3 content was determined in B12-deficient rats, and the effect of the administration of methylcobalamin (CH3-B12) on the serum C3 content was also studied. It was found that the serum C3 content in rats fed on a vitamin B12-deficient diet for 90 and 120 days significantly decreased compared with that in control rats. The administration of CH3-B12) restored the serum C3 content to control levels. The above results indicate that B12-deficiency depressed the serum C3 content and lowered humoral immunocompetence, and that these changes were ascribable to B12-deficiency. |
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Authors:
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M Wada; T Kawata; K Yamada; U Funada; M Kuwamori; M Endo; N Tanaka; T Tadokoro; A Maekawa |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition Volume: 68 ISSN: 0300-9831 ISO Abbreviation: Int J Vitam Nutr Res Publication Date: 1998 |
Date Detail:
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Created Date: 1998-06-08 Completed Date: 1998-06-08 Revised Date: 2007-02-21 |
Medline Journal Info:
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Nlm Unique ID: 1273304 Medline TA: Int J Vitam Nutr Res Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 94-7 Citation Subset: IM |
Affiliation:
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Department of Nutrition, Faculty of Agriculture, Tokyo University of Agriculture, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Proteins / metabolism Complement C3 / metabolism* Diet Male Methylmalonic Acid / urine Rats Rats, Wistar Vitamin B 12 / administration & dosage, analogs & derivatives, therapeutic use Vitamin B 12 Deficiency / blood*, drug therapy, immunology |
| Chemical | |
Reg. No./Substance:
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0/Blood Proteins; 0/Complement C3; 13422-55-4/mecobalamin; 516-05-2/Methylmalonic Acid; 68-19-9/Vitamin B 12 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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