Document Detail

Serum C3 content in vitamin B(12)-deficient rats.
MedLine Citation:
PMID:  9565823     Owner:  NLM     Status:  MEDLINE    
As a clue to clarifying the role of vitamin B12 (B12) in the function of the complement system, serum C3 content was determined in B12-deficient rats, and the effect of the administration of methylcobalamin (CH3-B12) on the serum C3 content was also studied. It was found that the serum C3 content in rats fed on a vitamin B12-deficient diet for 90 and 120 days significantly decreased compared with that in control rats. The administration of CH3-B12) restored the serum C3 content to control levels. The above results indicate that B12-deficiency depressed the serum C3 content and lowered humoral immunocompetence, and that these changes were ascribable to B12-deficiency.
M Wada; T Kawata; K Yamada; U Funada; M Kuwamori; M Endo; N Tanaka; T Tadokoro; A Maekawa
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition     Volume:  68     ISSN:  0300-9831     ISO Abbreviation:  Int J Vitam Nutr Res     Publication Date:  1998  
Date Detail:
Created Date:  1998-06-08     Completed Date:  1998-06-08     Revised Date:  2007-02-21    
Medline Journal Info:
Nlm Unique ID:  1273304     Medline TA:  Int J Vitam Nutr Res     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  94-7     Citation Subset:  IM    
Department of Nutrition, Faculty of Agriculture, Tokyo University of Agriculture, Japan.
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MeSH Terms
Blood Proteins / metabolism
Complement C3 / metabolism*
Methylmalonic Acid / urine
Rats, Wistar
Vitamin B 12 / administration & dosage,  analogs & derivatives,  therapeutic use
Vitamin B 12 Deficiency / blood*,  drug therapy,  immunology
Reg. No./Substance:
0/Blood Proteins; 0/Complement C3; 13422-55-4/mecobalamin; 516-05-2/Methylmalonic Acid; 68-19-9/Vitamin B 12

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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