Document Detail


Serum C-reactive protein and lipid hydroperoxides in predicting short-term clinical outcome after spontaneous intracerebral hemorrhage.
MedLine Citation:
PMID:  21172733     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
There is no effective treatment for spontaneous intracerebral hemorrhage (sICH). We examined 46 patients with sICH within 48 hours after onset of symptoms, aiming to assess the predictive value of C-reactive protein (CRP) and lipid hydroperoxides (ROOH) on "first-week mortality" and "clinical outcome at discharge" by binary logistic regression. We found that serum CRP and hematoma volume were predictors of short-term mortality. Although serum ROOH level was positively correlated with mortality, it did not predict early lethal outcome. Serum ROOH concentration, however, was a predictor of poor clinical outcome in sICH survivors. After confirmation of the results obtained through observing a larger group of patients, an oxidative stress marker could be used as an additional criterion for patient stratification, especially when severe disability is expected and supplementary therapeutic approaches are urgent.
Authors:
Margarita L Alexandrova; Maya P Danovska
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Publication Detail:
Type:  Journal Article     Date:  2010-12-18
Journal Detail:
Title:  Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia     Volume:  18     ISSN:  1532-2653     ISO Abbreviation:  J Clin Neurosci     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-01-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9433352     Medline TA:  J Clin Neurosci     Country:  Scotland    
Other Details:
Languages:  eng     Pagination:  247-52     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Ltd. All rights reserved.
Affiliation:
Department of Biophysics, Medical University, 1 Kliment Ohridski Street, Pleven 5800, Bulgaria.
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