Document Detail

Serum Biomarkers of MRI Brain Injury in Neonatal Hypoxic Ischemic Encephalopathy Treated With Whole-Body Hypothermia: A Pilot Study.
MedLine Citation:
PMID:  23392373     Owner:  NLM     Status:  Publisher    
OBJECTIVES:: To determine if candidate biomarkers, ubiquitin carboxyl-terminal esterase L1 and glial fibrillary acidic protein, are elevated in neonates with hypoxic ischemic encephalopathy who die or have severe MRI injury compared with surviving infants with minimal or no injury on brain MRI. DESIGN:: Prospective observational study. SETTING:: Level IIIC outborn neonatal ICU in a free-standing children's hospital. PATIENTS:: Term newborns with moderate-to-severe hypoxic ischemic encephalopathy referred for therapeutic hypothermia INTERVENTIONS:: Serum specimens were collected at 0, 12, 24, and 72 hrs of cooling. MRI was performed in surviving infants at target 7-10 days of life and was scored by a pediatric neuroradiologist masked to biomarker and clinical data. MEASUREMENTS AND MAIN RESULTS:: Serial biomarker levels were determined in 20 hypoxic ischemic encephalopathy patients. Ubiquitin carboxyl-terminal esterase L1 was higher at initiation and 72 hrs of cooling, while glial fibrillary acidic protein was higher at 24 and 72 hrs in babies with adverse outcome compared with those with favorable outcome. CONCLUSIONS:: This preliminary data support further studies to evaluate ubiquitin carboxyl-terminal esterase L1 and glial fibrillary acidic protein as immediate biomarkers of cerebral injury severity in newborns with hypoxic ischemic encephalopathy.
An N Massaro; Andreas Jeromin; Nadja Kadom; Gilbert Vezina; Ronald L Hayes; Kevin K W Wang; Jackson Streeter; Michael V Johnston
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-2-7
Journal Detail:
Title:  Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies     Volume:  -     ISSN:  1529-7535     ISO Abbreviation:  Pediatr Crit Care Med     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-2-8     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100954653     Medline TA:  Pediatr Crit Care Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
1 Department of Neonatology, Children's National Medical Center, WA. 2 Banyan Biomarkers, Alachua, FL. 3 Department ofNeuroradiology, Children's National Medical Center, WA. 4 Department of Neuroscience, The Hugo W. Moser Research Institute at Kennedy-Krieger, Baltimore, MD.
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