| Serum Bilirubin Level is Negatively Correlated With Disease Progression of Peripheral Arterial Disease: An Observational Cohort Study. | |
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MedLine Citation:
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PMID: 22072643 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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We determined whether low bilirubin level is a risk factor for peripheral arterial disease (PAD). We recruited 318 patients with PAD and 100 healthy volunteers. Patients were divided into 4 groups by the Fontaine classification for PAD, namely, group 1 (grade 1, n = 4); group 2 (grade 2, n = 114), group 3 (grade 3, n = 164), and group 4 (grade 4, n = 36). Total bilirubin (T-BIL), direct bilirubin (D-BIL), and indirect bilirubin (I-BIL) levels were compared using stepwise multiple regressions adjusted for selected factors. After adjusting for gender, age, smoking, and diastolic blood pressure, serum levels of T-BIL, D-BIL, and I-BIL were significantly lower in the PAD group (P < .05). Patients with grade 4 PAD showed significantly (P < .05) lower levels of T-BIL when compared with grade 2 patients. We concluded that serum bilirubin levels are negatively correlated with the severity and progression of PAD. |
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Authors:
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Hai-Yang Wang; Peng Han; Wei-Hui Zhang; Bing Liu; Ha-Li Li; Hai-Jun Wang; Ren-Ping Huang |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-11-8 |
Journal Detail:
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Title: Angiology Volume: - ISSN: 1940-1574 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-11-10 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0203706 Medline TA: Angiology Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of General Surgery, First Clinical College, Harbin Medical University, Harbin, Heilongjiang, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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