| Serum BMP-4 levels in relation to arterial stiffness and carotid atherosclerosis in patients with Type 2 diabetes. | |
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MedLine Citation:
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PMID: 22103619 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Aim: The aim of this study was to evaluate the association between the circulating BMP-4 levels and atherosclerosis in patients with Type 2 diabetes. Material & methods: Serum BMP-4 levels were measured in 174 diabetic patients, and the degree of atherosclerosis was assessed by measuring the carotid intima-media thickness and the cardio-ankle vascular index. Results: Serum BMP-4 levels were inversely correlated with systolic blood pressure, triglycerides, free fatty acids, cardio-ankle vascular index and carotid intima-media thickness. Lower BMP-4 levels were shown to be an independent predictor of the increased cardio-ankle vascular index and carotid intima-media thickness after adjusting for conventional cardiovascular risk factors in patients with Type 2 diabetes. Conclusion: Serum BMP-4 levels are inversely associated with surrogate markers of arterial stiffness and carotid atherosclerosis in patients with Type 2 diabetes. |
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Authors:
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Jang-Won Son; Eun-Hee Jang; Mee-Kyoung Kim; Ki-Hyun Baek; Ki-Ho Song; Kun-Ho Yoon; Bong-Yun Cha; Ho-Young Son; Kwang-Woo Lee; Hanjoong Jo; Hyuk-Sang Kwon |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Biomarkers in medicine Volume: 5 ISSN: 1752-0371 ISO Abbreviation: Biomark Med Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-11-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101312535 Medline TA: Biomark Med Country: England |
Other Details:
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Languages: eng Pagination: 827-35 Citation Subset: IM |
Affiliation:
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Division of Endocrinology and Metabolism, Department of Internal Medicine, The Catholic University of Korea, Bucheon St Mary's Hospital, Bucheon, Republic of Korea. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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