Document Detail

Serum BAFF and APRIL might be associated with disease activity and kidney damage in patients with anti-GBM disease.
MedLine Citation:
PMID:  23317407     Owner:  NLM     Status:  Publisher    
AIMS: B cell activating factor belonging to tumor necrosis factor family (BAFF) and a proliferation inducing ligand (APRIL) are two TNF-like cytokines those were found to be elevated in many autoimmune diseases. Anti-glomerular basement membrane (GBM) disease is a typical severe autoimmune disease characterized by raised serum anti-GBM antibodies. In this study we aimed to detect the serum levels of BAFF and APRIL in patients with anti-GBM disease, and their clinical significance was further analyzed. METHODS: Forty seven patients with anti-GBM disease were enrolled in this study. Forty eight healthy individuals were used as normal controls. The levels of serum BAFF and APRIL were assessed using commercial available ELISA kits. The association between the levels of serum BAFF and APRIL, and the clinical and pathological parameters were further evaluated. RESULTS: The serum levels of BAFF and APRIL in patients with anti-GBM disease were significantly higher than that in normal controls (12.3±14.1 ng/ml vs. 0.9±0.3 ng/ml, P<0.001; 19.1±22.9 ng/ml vs. 1.6±4.6 ng/ml, P<0.001), respectively. The levels of serum APRIL were correlated with the titers of anti-GBM antibodies (r=0.347, P=0.041), the levels of serum BAFF were associated with the percentage of glomeruli with crescents (r=0.482, P=0.015) in patients with anti-GBM disease. CONCLUSION: The levels of serum BAFF and APRIL were raised in patients with anti-GBM disease and might be associated with disease activity and kidney damage.
Gang Xin; Zhao Cui; Yun Su; Li-Xia Xu; Ming-Hui Zhao; Kang-Sheng Li
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-15
Journal Detail:
Title:  Nephrology (Carlton, Vic.)     Volume:  -     ISSN:  1440-1797     ISO Abbreviation:  Nephrology (Carlton)     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9615568     Medline TA:  Nephrology (Carlton)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2013 The Authors. Nephrology © 2013 Asian Pacific Society of Nephrology.
Department of Microbiology and Immunology, Shantou University Medical College, Shantou, 515041, Guangdong, P.R. China.
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