| Serum adiponectin, TNF-α, IL-12p70, and IL-13 levels in multiple sclerosis and the effects of different therapy regimens. | |
| | |
MedLine Citation:
|
PMID: 20714168 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
OBJECTIVES: Multiple sclerosis (MS) is a chronic inflammatory disease of the human central nervous system. In the present study, we aimed to determine adiponectin, tumor necrosis factor-α, interleukin (IL)-12p70, and IL-13 levels in the sera of patients with MS and to investigate the effects of interferon (IFN), glatiramer acetate (GA), and immunosuppressive treatment regimens on these parameters. METHODS: Fifty-seven patients with MS and 34 healthy controls were enrolled into the study. Serum cytokine levels were measured using enzyme immunoassay. RESULTS: Significantly elevated levels of IL-12p70 and IL-13 were found in the sera of patients with MS, but decreased adiponectin levels were found in patients' sera compared to healthy controls. The levels of IL-12p70 and IL-13 in the IFN therapy group were higher than those of the healthy controls. However, the IL-12p70 and IL-13 levels in the GA therapy group were not different from those of the healthy controls. There were no differences with regard to adiponectin levels among the subgroups of patients with MS according to therapy regimen and the healthy controls. At the end of a 2-year follow-up period, Expanded Disability Status Scale (EDSS) values were found to be increased in the IFN therapy group but unchanged in the GA therapy group. CONCLUSIONS: These findings suggest that adiponectin, IL-12p70, and IL-13 may play a role in the pathogenesis of MS. Additionally, GA therapy regimens in MS are more effective than IFN therapy with respect to decreasing the levels of IL-12p70 and IL-13 and stabilizing the EDSS value. |
| | |
Authors:
|
Ugur Musabak; Seref Demirkaya; Gencer Genç; Rahsan Sagkan Ilikci; Zeki Odabasi |
Related Documents
:
|
3537648 - Multiple sclerosis: decreased relapse rate through dietary supplementation with calcium... 8117478 - Trigeminal neuralgia: a cautionary tale. 17950788 - Impact of the metabolic syndrome on angiographic and clinical events after coronary int... 15721518 - Heart rate variability in adult patients with isolated left ventricular noncompaction. 7281088 - Pulmonary involvement in primary biliary cirrhosis. 20203528 - Link between interleukin-10 level and outcome after ischemic stroke. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-08-17 |
Journal Detail:
|
Title: Neuroimmunomodulation Volume: 18 ISSN: 1423-0216 ISO Abbreviation: Neuroimmunomodulation Publication Date: 2011 |
Date Detail:
|
Created Date: 2010-09-30 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9422763 Medline TA: Neuroimmunomodulation Country: Switzerland |
Other Details:
|
Languages: eng Pagination: 57-66 Citation Subset: IM |
Copyright Information:
|
Copyright © 2010 S. Karger AG, Basel. |
Affiliation:
|
Department of Immunology, Gulhane Military Medical Academy and School of Medicine, Ankara, Turkey. umusabak@hotmail.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: C-Reactive Protein and Mortality in Hemodialysis Patients: The Dialysis Outcomes and Practice Patter...
Next Document: Associations between brain-derived neurotrophic factor plasma levels and severity of the illness, re...