Document Detail

Serum adiponectin relates to shortened overall survival in men with squamous cell esophageal cancer treated with preoperative concurrent chemoradiotherapy: a pilot study.
MedLine Citation:
PMID:  25408239     Owner:  NLM     Status:  In-Data-Review    
Background The convergence of nutritional, genetic, and inflammatory factors plays a significant role in the pathophysiology of squamous cell esophageal cancer (SCEC). The parameters of inflammation, indices of nutritional status, and adipocyte-derived hormones such as leptin, adiponectin, and resistin have been shown to be prognostic factors in some gastrointestinal and pancreatic cancers. Material and Methods Forty-two patients with SCEC were subjected to a multimodal regimen of concurrent neoadjuvant chemoradiotherapy (CRT) followed by surgery. We retrospectively analyzed the impact of pretreatment values of serum leptin, adiponectin, resistin, soluble leptin receptor, C-reactive protein, TNF alpha, leukocytes, and indices of nutritional status (BMI, plasma total protein, albumin, cholesterol, and triacylglycerols) on overall survival (OS). Results Univariate analysis revealed significant a negative correlation between OS and serum adiponectin (p=0.027), and a positive relationship was found between serum albumin (p=0.002), cholesterol (p=0.049) level, and OS. In multivariate analysis, only the trend (p=0.086) for negative serum adiponectin association with the OS was observed. Conclusions In men with SCEC treated by neoadjuvant concurrent CRT and esophagectomy, high pretreatment level of serum adiponectin was associated with shorter OS while the serum albumin and cholesterol were associated with longer OS.
Milada Zemanová; Barbora Staňková; Zuzana Ušiakova; Eva Tvrzická; Alexandr Pazdro; Luboš Petruželka; Miroslav Zeman
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Publication Detail:
Type:  Journal Article     Date:  2014-11-19
Journal Detail:
Title:  Medical science monitor : international medical journal of experimental and clinical research     Volume:  20     ISSN:  1643-3750     ISO Abbreviation:  Med. Sci. Monit.     Publication Date:  2014  
Date Detail:
Created Date:  2014-11-21     Completed Date:  -     Revised Date:  2014-12-02    
Medline Journal Info:
Nlm Unique ID:  9609063     Medline TA:  Med Sci Monit     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2351-7     Citation Subset:  IM    
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