| Serum adiponectin, leptin, C-peptide, homocysteine, and colorectal adenoma recurrence in the Polyp Prevention Trial. | |
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MedLine Citation:
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PMID: 20501764 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Serum adiponectin, leptin, C-peptide, and homocysteine are indicators for obesity, hyperinsulinemia, and chronic inflammation, which have all been associated with colorectal cancer. AIMS: To determine whether serum adiponectin, leptin, C-peptide, and homocysteine are associated with fat, fiber, fruit and vegetable, flavonol, or dry bean intake and colorectal adenoma recurrence. METHODS: Using logistic regression, we estimated odds ratios (OR) and 95% confidence intervals (95% CI) for adenoma recurrence in 627 participants from the control arm of the Polyp Prevention Trial, a 4-year trial that examined the effectiveness of a low-fat, high-fiber, high-fruit and vegetable diet on adenoma recurrence. RESULTS: Serum concentrations of C-peptide and homocysteine were inversely related to fiber, fruit and vegetable, and flavonol intake and positively related to percentage of calories from fat (all P(trend) < or = 0.01). High homocysteine concentrations were associated with any (4th versus 1st quartile: OR, 2.26; 95% CI, 1.30-3.94) and more than one adenoma recurrence (OR, 2.11; 95% CI, 1.01-4.40). Individuals in the highest, versus lowest, tertile of serum leptin concentration had a decreased risk of advanced adenoma recurrence (OR, 0.22; 95% CI, 0.06-0.79). CONCLUSION: Our results suggest that serum homocysteine may serve as an indicator of dietary exposure, including a low-fat and high-fiber, high-fruit and vegetable, and high-flavonol diet, as well as colorectal adenoma recurrence. IMPACT: Discovering biomarkers that are both modifiable and can predict cancer risk is critical. We identified serum homocysteine as a novel indicator that is modified by diet and predicts risk of adenoma recurrence. |
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Authors:
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Gerd Bobe; Gwen Murphy; Connie J Rogers; Kenneth W Hance; Paul S Albert; Adeyinka O Laiyemo; Leah B Sansbury; Elaine Lanza; Arthur Schatzkin; Amanda J Cross |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Intramural Date: 2010-05-25 |
Journal Detail:
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Title: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology Volume: 19 ISSN: 1538-7755 ISO Abbreviation: Cancer Epidemiol. Biomarkers Prev. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-06-09 Completed Date: 2010-10-15 Revised Date: 2011-07-28 |
Medline Journal Info:
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Nlm Unique ID: 9200608 Medline TA: Cancer Epidemiol Biomarkers Prev Country: United States |
Other Details:
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Languages: eng Pagination: 1441-52 Citation Subset: IM |
Copyright Information:
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Copyright 2010 AACR. |
Affiliation:
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Laboratory of Cancer Prevention, Center for Cancer Research, National Cancer Institute (NCI), NIH, Department of Health and Human Services (DHHS), Bethesda, Maryland, USA. gerd.bobe@oregonstate.edu |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenoma
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blood*,
prevention & control Adiponectin / blood Adult Aged Aged, 80 and over C-Peptide / blood Colorectal Neoplasms / blood*, prevention & control Diet Female Follow-Up Studies Homocysteine / blood Humans Leptin / blood Male Middle Aged Neoplasm Recurrence, Local / blood*, pathology Recurrence Risk Factors |
| Grant Support | |
ID/Acronym/Agency:
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Z01 CN000151-19/CN/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Adiponectin; 0/C-Peptide; 0/Leptin; 454-28-4/Homocysteine |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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