Document Detail

Serum Adiponectin, Anemia and Left Ventricular Dimensions in Patients with Cardiac Cachexia.
MedLine Citation:
PMID:  24051989     Owner:  NLM     Status:  Publisher    
Objectives: Our study aims to determine the role of serum adiponectin in chronic heart failure (CHF) and cardiac cachexia (CC). Methods: Ninety consecutive patients were included in the study. Patients were divided into three groups: 30 CHF patients with CC, 30 CHF patients without CC, and 30 healthy individuals. Adiponectin levels were measured through human ELISA kits. Results: Levels of serum adiponectin were significantly higher in the CHF patients with cachexia in comparison with the other groups (CHF with CC: 58.4 ± 15.5 ng/ml vs. CHF without CC: 24 ± 6.7 ng/ml and controls: 7.7 ± 3.4 ng/ml; p = 0.001). Serum adiponectin was negatively correlated with BMI, high-sensitivity C-reactive protein, and hemoglobin (r = -0.37, p = 0.02; r = -0.29, p = 0.02; r = -0.18, p = 0.03, respectively) in the CHF patients with cachexia. Additionally, serum adiponectin levels were positively correlated with B-type natriuretic protein levels, left ventricle end-diastolic and end-systolic diameters (r = 0.36, p = 0.02; r = 0.46, p = 0.01; r = 0.49, p = 0.006, respectively) in the CHF patients with cachexia. Conclusion: Our findings suggest that adiponectin may play a critical role in the pathogenesis of cardiac remodeling and anemia in CC.
Evin Bozcali; Veli Polat; Handan Akbulut; Mustafa Ferzeyn Yavuzkir; Ilgin Karaca
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-9-18
Journal Detail:
Title:  Cardiology     Volume:  126     ISSN:  1421-9751     ISO Abbreviation:  Cardiology     Publication Date:  2013 Sep 
Date Detail:
Created Date:  2013-9-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1266406     Medline TA:  Cardiology     Country:  -    
Other Details:
Languages:  ENG     Pagination:  207-213     Citation Subset:  -    
Copyright Information:
Copyright © 2013 S. Karger AG, Basel.
Department of Cardiology, Baltalimani Bone Diseases Education and Research Hospital, Istanbul, Turkey.
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