| Serum 25-hydroxyvitamin D and parathyroid hormone are independent determinants of whole-body insulin sensitivity in women and may contribute to lower insulin sensitivity in African Americans. | |
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MedLine Citation:
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PMID: 20861177 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Circulating 25-hydroxyvitamin D [25(OH)D] and parathyroid hormone (PTH) concentrations have been shown to be associated with insulin sensitivity; however, adiposity may confound this relation. Furthermore, African Americans (AAs) have lower insulin sensitivity and 25(OH)D concentrations than do European Americans (EAs); whether these differences are associated in a cause-and-effect manner has not been determined. OBJECTIVES: The objectives of this study were to examine the relation of 25(OH)D and PTH concentrations with whole-body insulin sensitivity and to determine whether lower 25(OH)D concentrations in AAs compared with EAs contribute to the lower insulin sensitivity of AAs relative to that of EAs. DESIGN: This was a cross-sectional study of 25 AA and 25 EA women. We determined the whole-body insulin sensitivity index (S(I)) with an intravenous glucose tolerance test and minimal modeling. Percentage body fat was determined with dual-energy X-ray absorptiometry, and intraabdominal adipose tissue (IAAT) was determined with computed tomography. RESULTS: Multiple linear regression analysis indicated that 25(OH)D and PTH concentrations were independent determinants of S(I) [standardized β = 0.24 (P = 0.04) and -0.36 (P = 0.002), respectively] after adjustment for age, race, and IAAT. The mean ethnic difference in S(I) decreased from 2.70 [· 10(-4) · min⁻¹/(μIU/mL)] after adjustment for IAAT and percentage body fat to 1.80 [· 10(-4) · min⁻¹/(μIU/mL)] after further adjustment for 25(OH)D and PTH concentrations. CONCLUSIONS: 25(OH)D and PTH concentrations were independently associated with whole-body insulin sensitivity in a cohort of healthy women, which suggested that these variables may influence insulin sensitivity through independent mechanisms. Furthermore, ethnic differences in 25(OH)D concentrations may contribute to ethnic differences in insulin sensitivity. |
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Authors:
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Jessica A Alvarez; Ambika P Ashraf; Gary R Hunter; Barbara A Gower |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-09-22 |
Journal Detail:
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Title: The American journal of clinical nutrition Volume: 92 ISSN: 1938-3207 ISO Abbreviation: Am. J. Clin. Nutr. Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-24 Completed Date: 2010-12-23 Revised Date: 2011-12-21 |
Medline Journal Info:
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Nlm Unique ID: 0376027 Medline TA: Am J Clin Nutr Country: United States |
Other Details:
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Languages: eng Pagination: 1344-9 Citation Subset: AIM; IM |
Affiliation:
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Department of Nutrition Sciences and the Department of Pediatrics/Division of Pediatric Endocrinology and Metabolism, The Children's Hospital, University of Alabama at Birmingham, Birmingham, AL, USA. jalvar2@uab.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Absorptiometry, Photon Adult African Americans* Cross-Sectional Studies Female Glucose Tolerance Test Humans Insulin Resistance* / ethnology Linear Models Middle Aged Parathyroid Hormone / blood* Regression Analysis Risk Factors Sex Factors Vitamin D / analogs & derivatives*, blood Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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K12 HD043397/HD/NICHD NIH HHS; M01-RR-00032/RR/NCRR NIH HHS; P30-DK56336/DK/NIDDK NIH HHS; P60-DK079626/DK/NIDDK NIH HHS; R01-DK49779/DK/NIDDK NIH HHS; R01-DK51684/DK/NIDDK NIH HHS; R01-DK58278/DK/NIDDK NIH HHS; UL1RR025777/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Parathyroid Hormone; 1406-16-2/Vitamin D; 64719-49-9/25-hydroxyvitamin D |
| Comments/Corrections | |
Comment In:
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Am J Clin Nutr. 2011 Mar;93(3):672-3; author reply 673-4
[PMID:
21209228
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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