Document Detail

Serum 25-hydroxyvitamin D levels and mammographic density among premenopausal women in a multiethnic population.
MedLine Citation:
PMID:  20216557     Owner:  NLM     Status:  MEDLINE    
Although some evidence suggests a protective role of vitamin D against breast cancer, epidemiological findings are inconsistent. The current study investigated the relation of serum 25-hydroxyvitamin D (25(OH)D) levels with mammographic density. Baseline serum samples from 182 premenopausal women including 67 Caucasians and 74 Asians from a nutritional trial were analyzed for 25(OH)D. Mammographic density was assessed using a computer-assisted method. Serum 25(OH)D was not associated with mammographic density after adjustment for confounders (body mass index (BMI), age at mammogram, Asian ethnicity, age at first birth, parity and age at menarche). 25(OH)D levels were significantly lower in Asians than in Caucasians, but no significant ethnic differences in mammographic density were observed after adjusting for BMI. Although the current results indicate that serum 25(OH)D levels were not associated with mammographic density among premenopausal women, a possible protective effect of vitamin D against breast cancer may be mediated through other pathways.
W Chai; G Maskarinec; R V Cooney
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2010-03-10
Journal Detail:
Title:  European journal of clinical nutrition     Volume:  64     ISSN:  1476-5640     ISO Abbreviation:  Eur J Clin Nutr     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-06-02     Completed Date:  2010-11-30     Revised Date:  2014-09-22    
Medline Journal Info:
Nlm Unique ID:  8804070     Medline TA:  Eur J Clin Nutr     Country:  England    
Other Details:
Languages:  eng     Pagination:  652-4     Citation Subset:  IM    
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MeSH Terms
Asian Continental Ancestry Group
Body Mass Index
Breast / anatomy & histology*
Breast Neoplasms / blood,  prevention & control*
European Continental Ancestry Group
Image Processing, Computer-Assisted
Middle Aged
Vitamin D / analogs & derivatives*,  blood
Grant Support
R01 CA080843/CA/NCI NIH HHS; R01 CA080843-04/CA/NCI NIH HHS; R01CA80843/CA/NCI NIH HHS; R03 CA130061/CA/NCI NIH HHS; R03 CA130061-02/CA/NCI NIH HHS; R03CA130061/CA/NCI NIH HHS; R25 CA090956/CA/NCI NIH HHS; R25 CA090956-07/CA/NCI NIH HHS; S10RR020890/RR/NCRR NIH HHS
Reg. No./Substance:
1406-16-2/Vitamin D; 64719-49-9/25-hydroxyvitamin D

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