| Serum 25-hydroxyvitamin D is independently associated with high-density lipoprotein cholesterol and the metabolic syndrome in men and women. | |
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MedLine Citation:
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PMID: 21291826 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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BACKGROUND: Low vitamin D status has been associated with markers of cardiovascular disease risk. OBJECTIVE: This cross-sectional study assessed the relationships between serum 25-hydroxyvitamin D [25(OH)D] and selected markers for cardiovascular disease risk, including metabolic syndrome and its components, in adult men and women. METHODS: Fasting blood samples, anthropometric measurements, and blood pressure were assessed in 257 men and women. Dietary intake was assessed with food frequency and dietary supplement questionnaires. RESULTS: Total vitamin D intake and that from dietary supplements were significantly associated with increasing serum 25(OH)D tertile (both P < .001). Mean±SEM serum high-density lipoprotein cholesterol (HDL-C) increased in a graded fashion (P < .001) from the lowest (48.4±1.8mg/dL) to the highest (62.3±2.1mg/dL) 25(OH)D tertile. The relationship between 25(OH)D and HDL-C remained significant (P < .001) after adjustment for established determinants of the HDL-C, with each 10-ng/mL increase in 25(OH)D associated with a 4.2-mg/dL increase in HDL-C concentration. Serum triglycerides (P=.008), waist circumference (P < .001), and body mass index (P < .001) showed graded, inverse relationships with 25(OH)D tertile, and the prevalence of metabolic syndrome decreased significantly from the lowest to the highest 25(OH)D tertile (31%, 14%, and 10%, respectively, P for trend=.001). CONCLUSIONS: Lower serum 25(OH)D is associated with the metabolic syndrome and adverse values for some metabolic syndrome risk factors, particularly the HDL-C concentration. Research is warranted to assess whether increasing vitamin D intake will improve the metabolic cardiovascular risk factor profile. |
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Authors:
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Kevin C Maki; Martyn R Rubin; Les G Wong; Jamie F McManus; Christopher D Jensen; John W Marshall; Andrea Lawless |
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Publication Detail:
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Type: Journal Article Date: 2009-07-17 |
Journal Detail:
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Title: Journal of clinical lipidology Volume: 3 ISSN: 1933-2874 ISO Abbreviation: J Clin Lipidol Publication Date: 2009 Aug |
Date Detail:
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Created Date: 2011-02-04 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101300157 Medline TA: J Clin Lipidol Country: United States |
Other Details:
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Languages: eng Pagination: 289-96 Citation Subset: - |
Affiliation:
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Provident Clinical Research, 489 Taft Avenue, Glen Ellyn, IL 60137 USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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