Document Detail

Serum 25-hydroxyvitamin D concentration is associated with functional capacity in older adults with heart failure.
MedLine Citation:
PMID:  21095277     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Vitamin D is a fat-soluble hormone necessary for calcium homeostasis. Recently, studies have demonstrated that vitamin D may be important to the health of the cardiovascular system.
METHODS: Adults ≥ 50 years of age with heart failure were recruited for assessment of serum 25-hydroxyvitamin D (25OHD) concentrations. Cardiopulmonary exercise testing was used to assess functional capacity. Proximal muscle strength was evaluated with a Biodex isokinetic dynamometer [corrected] (Biodex, Shirley, NY), and health status was assessed with the Kansas City Cardiomyopathy Questionnaire. Univariate associations between physical performance and health status measures and 25OHD followed by a linear regression model were used to study associations, adjusting for other potential explanatory variables.
RESULTS: Forty adults 67.8 ± 10.9 years of age (55% women and 57.5% African American) with mean ejection fraction 40% were analyzed (New York Heart Association class II in 70% and class III in 30%). Comorbidities included 77.5% hypertension and 47.5% diabetes. The mean 25OHD concentration was 18.5 ± 9.1 ng/mL, and mean peak Vo₂, 14 ± 4 mL/kg/min. In univariate regression analysis, 25OHD was positively associated with peak Vo₂ (P = .045). Multivariable regression analysis sustained positive association between 25OHD and peak Vo₂ (P = .044) after adjusting for age, race, and respiratory exchange ratio (adjusted R² = 0.32). Association between proximal muscle strength with the 25OHD concentration was not significant. The Kansas City Cardiomyopathy Questionnaire physical limitation domain score was negatively associated with 25OHD (P = .04) but was not sustained in multivariable analysis.
CONCLUSIONS: 25-Hydroxyvitamin D may be an important marker or modulator of functional capacity in patients with heart failure. Randomized controlled trials are needed to assess the effect of vitamin D repletion on functional performance.
Rebecca S Boxer; Anne M Kenny; Vinay K Cheruvu; Marianne Vest; Justin J Fiutem; Ileana I Piña
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Publication Detail:
Type:  Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American heart journal     Volume:  160     ISSN:  1097-6744     ISO Abbreviation:  Am. Heart J.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-11-24     Completed Date:  2011-01-18     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  0370465     Medline TA:  Am Heart J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  893-9     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2010 Mosby, Inc. All rights reserved.
Department of Medicine, Case Western Reserve University, Cleveland, OH, USA.
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MeSH Terms
Biological Markers / blood
Double-Blind Method
Exercise Test
Exercise Tolerance / physiology*
Follow-Up Studies
Heart Failure / blood*,  drug therapy,  physiopathology
Middle Aged
Muscle Strength / physiology
Severity of Illness Index
Stroke Volume / physiology
Vitamin D / administration & dosage*,  analogs & derivatives*,  blood,  pharmacokinetics
Vitamins / administration & dosage,  pharmacokinetics
Grant Support
Reg. No./Substance:
0/Biological Markers; 0/Vitamins; 1406-16-2/Vitamin D; 64719-49-9/25-hydroxyvitamin D
Erratum In:
Am Heart J. 2011 Feb;161(2):425

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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