| Serum 25-hydroxyvitamin D concentration is associated with functional capacity in older adults with heart failure. | |
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MedLine Citation:
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PMID: 21095277 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Vitamin D is a fat-soluble hormone necessary for calcium homeostasis. Recently, studies have demonstrated that vitamin D may be important to the health of the cardiovascular system. METHODS: Adults ≥ 50 years of age with heart failure were recruited for assessment of serum 25-hydroxyvitamin D (25OHD) concentrations. Cardiopulmonary exercise testing was used to assess functional capacity. Proximal muscle strength was evaluated with a Biodex isokinetic dynamometer [corrected] (Biodex, Shirley, NY), and health status was assessed with the Kansas City Cardiomyopathy Questionnaire. Univariate associations between physical performance and health status measures and 25OHD followed by a linear regression model were used to study associations, adjusting for other potential explanatory variables. RESULTS: Forty adults 67.8 ± 10.9 years of age (55% women and 57.5% African American) with mean ejection fraction 40% were analyzed (New York Heart Association class II in 70% and class III in 30%). Comorbidities included 77.5% hypertension and 47.5% diabetes. The mean 25OHD concentration was 18.5 ± 9.1 ng/mL, and mean peak Vo₂, 14 ± 4 mL/kg/min. In univariate regression analysis, 25OHD was positively associated with peak Vo₂ (P = .045). Multivariable regression analysis sustained positive association between 25OHD and peak Vo₂ (P = .044) after adjusting for age, race, and respiratory exchange ratio (adjusted R² = 0.32). Association between proximal muscle strength with the 25OHD concentration was not significant. The Kansas City Cardiomyopathy Questionnaire physical limitation domain score was negatively associated with 25OHD (P = .04) but was not sustained in multivariable analysis. CONCLUSIONS: 25-Hydroxyvitamin D may be an important marker or modulator of functional capacity in patients with heart failure. Randomized controlled trials are needed to assess the effect of vitamin D repletion on functional performance. |
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Authors:
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Rebecca S Boxer; Anne M Kenny; Vinay K Cheruvu; Marianne Vest; Justin J Fiutem; Ileana I Piña |
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Publication Detail:
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Type: Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: American heart journal Volume: 160 ISSN: 1097-6744 ISO Abbreviation: Am. Heart J. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-11-24 Completed Date: 2011-01-18 Revised Date: 2013-05-27 |
Medline Journal Info:
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Nlm Unique ID: 0370465 Medline TA: Am Heart J Country: United States |
Other Details:
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Languages: eng Pagination: 893-9 Citation Subset: AIM; IM |
Copyright Information:
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Copyright © 2010 Mosby, Inc. All rights reserved. |
Affiliation:
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Department of Medicine, Case Western Reserve University, Cleveland, OH, USA. rebecca.boxer@case.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Biological Markers / blood Double-Blind Method Exercise Test Exercise Tolerance / physiology* Female Follow-Up Studies Heart Failure / blood*, drug therapy, physiopathology Humans Male Middle Aged Muscle Strength / physiology Prognosis Questionnaires Severity of Illness Index Stroke Volume / physiology Vitamin D / administration & dosage*, analogs & derivatives*, blood, pharmacokinetics Vitamins / administration & dosage, pharmacokinetics |
| Grant Support | |
ID/Acronym/Agency:
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KL2 RR024990/RR/NCRR NIH HHS; KL2RR024990/RR/NCRR NIH HHS; UL1 RR024989/RR/NCRR NIH HHS; UL1 RR024989/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Vitamins; 1406-16-2/Vitamin D; 64719-49-9/25-hydroxyvitamin D |
| Comments/Corrections | |
Erratum In:
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Am Heart J. 2011 Feb;161(2):425 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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