Document Detail


Serum 25-hydroxyvitamin D concentration and physical function in adult men.
MedLine Citation:
PMID:  21083597     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Recent reports suggest that vitamin D status influences musculoskeletal health; yet, there are limited data in adult men. This study investigated whether serum 25-hydroxyvitamin D [25(OH)D] concentration was associated with lean body mass, muscle strength and physical performance in men.
DESIGN: Population-based, observational survey.
PARTICIPANTS: 1219 black, Hispanic and white randomly selected men aged 30-79 years from the Boston Area Community Health/Bone Survey.
MEASUREMENTS: Lean body mass by dual-energy X-ray absorptiometry, hand grip strength, a composite physical function score (chair stand and walking speed), 25(OH)D, parathyroid hormone (PTH), testosterone, age, race, body mass index, socioeconomic status, education, smoking, arthritis, self-reported health, calcium intake, physical activity.
RESULTS: The distributions of serum 25(OH)D quartiles differed by race/ethnicity, education and smoking status. After adjustment for multiple lifestyle factors, serum 25(OH)D was not related to lean body mass, grip strength or the composite physical function score (all P>0.20). There was no variation in the associations between 25(OH)D level and outcomes by race/ethnicity. The relationship between PTH and the outcomes revealed similar results.
CONCLUSION: In this population-based sample of adult men with a broad age range, there was no association between serum 25(OH)D concentration and lean body mass, muscle strength and physical function after controlling for multiple lifestyle factors.
Authors:
Lisa Ceglia; Gretchen R Chiu; Susan S Harris; Andre B Araujo
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Clinical endocrinology     Volume:  74     ISSN:  1365-2265     ISO Abbreviation:  Clin. Endocrinol. (Oxf)     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-02-08     Completed Date:  2011-06-09     Revised Date:  2014-09-09    
Medline Journal Info:
Nlm Unique ID:  0346653     Medline TA:  Clin Endocrinol (Oxf)     Country:  England    
Other Details:
Languages:  eng     Pagination:  370-6     Citation Subset:  IM    
Copyright Information:
© 2011 Blackwell Publishing Ltd.
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MeSH Terms
Descriptor/Qualifier:
Absorptiometry, Photon
Adult
African Americans / statistics & numerical data
Aged
Body Mass Index*
Boston
European Continental Ancestry Group / statistics & numerical data
Hispanic Americans / statistics & numerical data
Humans
Male
Middle Aged
Multivariate Analysis
Muscle Strength / physiology*
Parathyroid Hormone / blood
Psychomotor Performance / physiology*
Social Class
Testosterone / blood
Vitamin D / analogs & derivatives*,  blood
Grant Support
ID/Acronym/Agency:
KL2 RR025752/RR/NCRR NIH HHS; R01 AG020727/AG/NIA NIH HHS; R01 AG020727-05A1/AG/NIA NIH HHS; R01AG020727/AG/NIA NIH HHS; U01DK056842/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Parathyroid Hormone; 1406-16-2/Vitamin D; 3XMK78S47O/Testosterone; 64719-49-9/25-hydroxyvitamin D
Comments/Corrections

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