Document Detail


Serum 1,5-anhydroglucitol levels in patients with fulminant type 1 diabetes are lower than those in patients with type 2 diabetes.
MedLine Citation:
PMID:  20709052     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: We investigated clinical relevance of serum 1,5-anhydroglucitol (1,5-AG) levels in fulminant type 1 diabetes mellitus (FT1DM) patients, because 1,5-AG is known to reflect short term glycemic control.
DESIGN AND METHODS: Subjects comprised 7 patients with FT1DM and 32 patients with type 2 diabetes mellitus (T2DM) with HbA1c <8.5%. All of them have never been treated for diabetes.
RESULTS: HbA(1C) showed no significant difference between both groups. On the other hand, serum 1,5-AG levels were significantly lower in the FT1DM patients than in the T2DM patients. Serum 1,5-AG levels were < 5.0 μg/ml in 6 of 7 (86%) FT1DM patients, compared with only 1 of 32 (3%) T2DM patients.
CONCLUSIONS: Serum 1,5-AG levels were lower in the FT1DM patients than in the T2DM patients. Serum 1,5-AG, but not HbA(1C), reflects short-term exacerbation of glycemia in patients with FT1DM.
Authors:
Masafumi Koga; Jun Murai; Hiroshi Saito; Mikio Mukai; Soji Kasayama; Akihisa Imagawa; Toshiaki Hanafusa
Publication Detail:
Type:  Journal Article     Date:  2010-08-12
Journal Detail:
Title:  Clinical biochemistry     Volume:  43     ISSN:  1873-2933     ISO Abbreviation:  Clin. Biochem.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-20     Completed Date:  2011-01-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0133660     Medline TA:  Clin Biochem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1265-7     Citation Subset:  IM    
Copyright Information:
Copyright © 2010. Published by Elsevier Inc.
Affiliation:
Department of Internal Medicine, Kinki Central Hospital, Hyogo, Japan. koga_m@kich.itami.hyogo.jp
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MeSH Terms
Descriptor/Qualifier:
Adult
Deoxyglucose / blood*
Diabetes Mellitus, Type 1 / blood*
Diabetes Mellitus, Type 2 / blood*
Female
Hemoglobin A, Glycosylated / metabolism
Humans
Male
Middle Aged
Chemical
Reg. No./Substance:
0/Hemoglobin A, Glycosylated; 154-17-6/Deoxyglucose; 154-58-5/1,5-anhydroglucitol

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