Document Detail

Sertraline and cocaine-induced locomotion in mice. I. Acute studies.
MedLine Citation:
PMID:  2057535     Owner:  NLM     Status:  MEDLINE    
The present study assessed the behavioral and pharmacokinetic interaction between the serotonin uptake blocker sertraline and cocaine in C57BL/6ByJ mice. Pretreatment with sertraline (1-32 mg/kg IP) did not affect the total amount of spontaneous locomotor activity during 50 min following administration of cocaine (15-40 mg/kg IP). At doses of sertraline (16 and 32 mg/kg) much higher than those found to inhibit ex vivo neuronal uptake of serotonin by 50% (1-2 mg/kg), the peak of cocaine-induced locomotor activity was shifted towards a later time. A similar effect was seen after pretreatment with serotonin uptake blockers other than sertraline, and also after desipramine. Sertraline (16 and 32 mg/kg), given 60 min prior to cocaine, did not affect levels of cocaine in brain and plasma, and cocaine administration did not alter the brain level of sertraline. Although female mice were more responsive to cocaine than male mice, they were not different in their response to sertraline.
M E Reith; H L Wiener; C T Fischette
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Psychopharmacology     Volume:  103     ISSN:  0033-3158     ISO Abbreviation:  Psychopharmacology (Berl.)     Publication Date:  1991  
Date Detail:
Created Date:  1991-08-01     Completed Date:  1991-08-01     Revised Date:  2008-09-06    
Medline Journal Info:
Nlm Unique ID:  7608025     Medline TA:  Psychopharmacology (Berl)     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  297-305     Citation Subset:  IM    
Center for Neurochemistry, N.S. Kline Institute for Psychiatric Research, New York, NY 10035.
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MeSH Terms
1-Naphthylamine / analogs & derivatives*,  pharmacokinetics,  pharmacology
Cocaine / pharmacokinetics,  pharmacology*
Desipramine / pharmacology
Dose-Response Relationship, Drug
Mice, Inbred C57BL
Motor Activity / drug effects*
Neurons / drug effects,  metabolism
Serotonin / metabolism
Serotonin Antagonists / pharmacokinetics,  pharmacology*
Sex Factors
Reg. No./Substance:
0/Serotonin Antagonists; 134-32-7/1-Naphthylamine; 50-36-2/Cocaine; 50-47-5/Desipramine; 50-67-9/Serotonin; 79617-96-2/Sertraline; 87857-41-8/desmethylsertraline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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