Document Detail

A Sertoli-Leydig cell tumor and pregnancy. Clinical, endocrine, radiologic, and electron microscopic findings.
MedLine Citation:
PMID:  6660923     Owner:  NLM     Status:  MEDLINE    
An extremely rare case of a conception occurring in a 26-year-old patient with a small virilizing Sertoli-Leydig cell tumor (diameter: 0.6 cm), bilateral polycystic ovaries and non-tumorous adrenal hyperandrogenism is presented. Prepregnancy findings included hirsutism, clitoromegaly, secondary amenorrhea, and elevated peripheral plasma testosterone (T; 5.7 ng/ml). Extensive basal steroid screening, dynamic function tests, conventional radiologic procedures, selective glandular vein catheterization, and laparoscopy failed to localize unequivocally the source of androgen excess, but suggested bilateral adrenal involvement. The patient conceived during the diagnostic work-up; peripheral T levels increased to 12.1 ng/ml within the first trimester. An exploratory laparotomy with left adrenalectomy, right adrenal biopsy and left ovarian wedge resection revealed an incompletely removed Sertoli-Leydig cell tumor, but normal adrenal histology. The pregnancy was terminated, a left oophorectomy and right ovarian wedge resection were performed at 14 weeks' gestation. Subsequently, peripheral androgens returned to normal, regular menses resumed, and hirsutism disappeared. Three years later the patient delivered a healthy female infant.
L Moltz; H Pickartz; R Sörensen; U Schwartz; J Hammerstein
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Archives of gynecology     Volume:  233     ISSN:  0170-9925     ISO Abbreviation:  Arch. Gynecol.     Publication Date:  1983  
Date Detail:
Created Date:  1984-02-24     Completed Date:  1984-02-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7901051     Medline TA:  Arch Gynecol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  295-308     Citation Subset:  IM    
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MeSH Terms
Abortion, Therapeutic
Hirsutism / etiology
Leydig Cell Tumor / diagnosis*
Ovarian Neoplasms / diagnosis*
Pregnancy Complications / diagnosis*
Sertoli Cell Tumor / diagnosis*
Testosterone / blood
Reg. No./Substance:

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