| Serpins in T cell immunity. | |
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MedLine Citation:
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PMID: 18641264 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Serine protease inhibitors (serpins) are a family of proteins that are important in the regulation of several biological processes. This mainly involves the inhibition of serine proteases, although some serpins inhibit a different class of proteases or even function without inhibitory activity. In contrast to other protease inhibitor families, serpins inhibit their target proteases by a specific mechanism, which depends on a change in conformation. This review primarily focuses on one subgroup of serpins--ovalbumin (ov)-serpins. Different than most members of the family, this group of serpins lacks secretion signal sequences and therefore, mainly functions intracellularly. In addition to expression in most normal tissues, ov-serpins can be found in multiple different cells of the immune system. Interestingly, expression of ov-serpins in these cells is tightly regulated, indicating a role for these serpins in the regulation of immune responses. The role of serpins in the immune response will be the topic of this review. |
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Authors:
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Michael Bots; Jan Paul Medema |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2008-07-18 |
Journal Detail:
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Title: Journal of leukocyte biology Volume: 84 ISSN: 0741-5400 ISO Abbreviation: J. Leukoc. Biol. Publication Date: 2008 Nov |
Date Detail:
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Created Date: 2008-10-15 Completed Date: 2008-11-18 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8405628 Medline TA: J Leukoc Biol Country: United States |
Other Details:
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Languages: eng Pagination: 1238-47 Citation Subset: IM |
Affiliation:
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Laboratory of Experimental Oncology and Radiobiology, Center for Experimental and Molecular Medicine, Academic Medical Center, Amsterdam, The Netherlands. michael.bots@petermac.org |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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CD8-Positive T-Lymphocytes
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immunology* Humans Immunologic Memory Neoplasms / immunology Ovalbumin / physiology Serpins / immunology*, metabolism T-Lymphocytes / immunology*, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Serpins; 9006-59-1/Ovalbumin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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