Document Detail


Serotypes of Escherichia coli in sudden infant death syndrome.
MedLine Citation:
PMID:  19674183     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIM: To examine the diversity of Escherichia coli serotypes found in the intestinal contents of infants who died of Sudden Infant Death Syndrome (SIDS) compared with that in comparison infants. METHODS AND RESULTS: Over the 3-year period, 1989-1991, in South Australia and Victoria (Australia), a total of 687 E. coli isolates from 231 patients with SIDS (348 isolates), 98 infants who had died from other causes (144 isolates) and 160 healthy infants (195 isolates) were studied. The isolates from patients with SIDS were found to represent 119 different serotypes; the isolates from 'other cause' infants represent 97 different serotypes; and the isolates from healthy infants represent 117 different serotypes. The seven common serotypes isolated most frequently from infants with SIDS belonged to those associated with extra-intestinal infections in humans. Compared to healthy infants (6%), these were found in significantly higher proportions among infants who died of other causes (13%, P < 0.05) or infants with SIDS (18.7%, P = 0.0002). CONCLUSIONS: Despite these sources yielding a wide variety of serotypes of E. coli, a pattern of certain potential pathotypes of E. coli being associated with SIDS is apparent. SIGNIFICANCE AND IMPACT OF THE STUDY: While SIDS remains one of the most important diagnoses of postneonatal death, its causes are still unexplained. If E. coli has a role in the pathogenesis of SIDS (as suggested by the pathotypes identified on the basis of serotype), further studies may reveal novel virulence factors that may clarify the role of this bacterium in SIDS.
Authors:
J L Pearce; K A Bettelheim; R K J Luke; P N Goldwater
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Publication Detail:
Type:  Journal Article     Date:  2009-07-13
Journal Detail:
Title:  Journal of applied microbiology     Volume:  108     ISSN:  1365-2672     ISO Abbreviation:  J. Appl. Microbiol.     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-05-04     Completed Date:  2010-07-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9706280     Medline TA:  J Appl Microbiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  731-5     Citation Subset:  IM    
Affiliation:
Department of Agricultural Sciences, La Trobe University, Melbourne, Vic., Australia.
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MeSH Terms
Descriptor/Qualifier:
Cause of Death
Escherichia coli / classification*,  isolation & purification,  pathogenicity
Escherichia coli Infections / complications*,  microbiology
Humans
Infant
Intestines / microbiology
Serotyping
South Australia
Sudden Infant Death / etiology*
Victoria

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