| Serotoninergic stimulation of aldosterone secretion in the rat in vivo: role of the renin-angiotensin system. | |
| | |
MedLine Citation:
|
PMID: 1719114 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Serotoninergic control of aldosterone secretion in vivo was investigated in conscious rats with indwelling arterial cannulae. Serial blood samples were taken from the animals before and after i.p. administration of 1 ml (4 g/l) 5-hydroxytryptophan (5-HTP), the precursor of serotonin, or saline and they were analysed for 5-HTP, serotonin, 5-hydroxyindoleacetic acid, plasma renin activity (PRA), corticosterone, aldosterone, sodium and potassium concentrations. The role of the renin-angiotensin system was investigated in animals pretreated for 1 week with the angiotensin-converting enzyme inhibitor captopril (25 mg/day). 5-HTP caused a significant increase in all parameters within 45 min except for sodium and potassium. Saline administration showed no significant effect. Captopril pretreatment did not impair the increase in any parameter by 5-HTP, with the exception of the aldosterone response which was significantly attenuated, though not completely. The results show that administration of 5-HTP, which increases serum serotonin levels, stimulates PRA, aldosterone and corticosterone secretion. Captopril pretreatment inhibits the aldosterone response, suggesting that the aldosterone stimulatory properties of 5-HTP require the presence of angiotensin II, although it is unclear whether it acts in a mediatory or permissive capacity. The failure of captopril to inhibit the aldosterone response completely suggests the involvement of other mechanisms such as the hypothalamo-pituitary adrenal axis or a direct action of serotonin on the adrenal. |
| | |
Authors:
|
E Davies; S Rossiter; C R Edwards; B C Williams |
Related Documents
:
|
8098604 - Treatment of macroprolactinoma with the new potent non-ergot d2-dopamine agonist quinag... 6273144 - Hypertension, hypokalemia and hypoaldosteronism with suppressed renin: a clinical study... 398494 - Hormonal response to volume depletion in non-nephrectomised patients on regular haemodi... 17102104 - Diagnostic value of biochemical parameters in the differential diagnosis of an adrenal ... 1970734 - Pharmacokinetics of epanolol in elderly patients with stable angina pectoris. 10477804 - Design of an intravaginal ring for the controlled delivery of 17 beta-estradiol as its ... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: The Journal of endocrinology Volume: 130 ISSN: 0022-0795 ISO Abbreviation: J. Endocrinol. Publication Date: 1991 Sep |
Date Detail:
|
Created Date: 1991-12-12 Completed Date: 1991-12-12 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0375363 Medline TA: J Endocrinol Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 347-55 Citation Subset: IM |
Affiliation:
|
Department of Medicine, Western General Hospital, Edinburgh. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
5-Hydroxytryptophan
/
blood,
pharmacology* Aldosterone / blood, secretion* Animals Captopril / pharmacology Corticosterone / blood Hydroxyindoleacetic Acid / blood Male Potassium / blood Rats Rats, Inbred Strains Renin / blood Renin-Angiotensin System / drug effects, physiology* Serotonin / blood Sodium / blood Stimulation, Chemical Time Factors |
| Chemical | |
Reg. No./Substance:
|
50-22-6/Corticosterone; 50-67-9/Serotonin; 52-39-1/Aldosterone; 54-16-0/Hydroxyindoleacetic Acid; 56-69-9/5-Hydroxytryptophan; 62571-86-2/Captopril; 7440-09-7/Potassium; 7440-23-5/Sodium; EC 3.4.23.15/Renin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Detection of estrogen and progesterone receptor bindings in mammary carcinoma cells: a comparative s...
Next Document: Administration of insulin-like growth factor-I, but not growth hormone, increases maternal weight ga...