Document Detail


Serotoninergic stimulation of aldosterone secretion in the rat in vivo: role of the renin-angiotensin system.
MedLine Citation:
PMID:  1719114     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Serotoninergic control of aldosterone secretion in vivo was investigated in conscious rats with indwelling arterial cannulae. Serial blood samples were taken from the animals before and after i.p. administration of 1 ml (4 g/l) 5-hydroxytryptophan (5-HTP), the precursor of serotonin, or saline and they were analysed for 5-HTP, serotonin, 5-hydroxyindoleacetic acid, plasma renin activity (PRA), corticosterone, aldosterone, sodium and potassium concentrations. The role of the renin-angiotensin system was investigated in animals pretreated for 1 week with the angiotensin-converting enzyme inhibitor captopril (25 mg/day). 5-HTP caused a significant increase in all parameters within 45 min except for sodium and potassium. Saline administration showed no significant effect. Captopril pretreatment did not impair the increase in any parameter by 5-HTP, with the exception of the aldosterone response which was significantly attenuated, though not completely. The results show that administration of 5-HTP, which increases serum serotonin levels, stimulates PRA, aldosterone and corticosterone secretion. Captopril pretreatment inhibits the aldosterone response, suggesting that the aldosterone stimulatory properties of 5-HTP require the presence of angiotensin II, although it is unclear whether it acts in a mediatory or permissive capacity. The failure of captopril to inhibit the aldosterone response completely suggests the involvement of other mechanisms such as the hypothalamo-pituitary adrenal axis or a direct action of serotonin on the adrenal.
Authors:
E Davies; S Rossiter; C R Edwards; B C Williams
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of endocrinology     Volume:  130     ISSN:  0022-0795     ISO Abbreviation:  J. Endocrinol.     Publication Date:  1991 Sep 
Date Detail:
Created Date:  1991-12-12     Completed Date:  1991-12-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375363     Medline TA:  J Endocrinol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  347-55     Citation Subset:  IM    
Affiliation:
Department of Medicine, Western General Hospital, Edinburgh.
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MeSH Terms
Descriptor/Qualifier:
5-Hydroxytryptophan / blood,  pharmacology*
Aldosterone / blood,  secretion*
Animals
Captopril / pharmacology
Corticosterone / blood
Hydroxyindoleacetic Acid / blood
Male
Potassium / blood
Rats
Rats, Inbred Strains
Renin / blood
Renin-Angiotensin System / drug effects,  physiology*
Serotonin / blood
Sodium / blood
Stimulation, Chemical
Time Factors
Chemical
Reg. No./Substance:
50-22-6/Corticosterone; 50-67-9/Serotonin; 52-39-1/Aldosterone; 54-16-0/Hydroxyindoleacetic Acid; 56-69-9/5-Hydroxytryptophan; 62571-86-2/Captopril; 7440-09-7/Potassium; 7440-23-5/Sodium; EC 3.4.23.15/Renin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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