Document Detail


Serotonin transporter polymorphism in Croatian patients with major depressive disorder.
MedLine Citation:
PMID:  16804504     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: Differences in serotonin transporter (SERT) expression and function produced by gene polymorphisms are associated with several behavioral and psychiatric traits. Two polymorphic regions of SERT gene: a 44-base-pair (bp) insertion / deletion polymorphism in the promoter region (SERTPR), and variable number of tandem repeats (VNTR) in second intron (SERT-in2) have been characterized. In this study we investigated the frequency distribution of polymorphic variants of short (S, s) and long (L, l) alleles, genotypes and haplotypes of SERTPR, and SERTin2, in patients with major depressive disorder (MDD) and compared it with results obtained from the Croatian healthy population. SUBJECTS AND METHODS: one hundred and fourteen patients who fulfilled DSM-IV criteria for a diagnosis of MDD were included in the study. Comparisons were made with the results obtained for 120 healthy volunteers representing a mixed Croatian population. SERT genotyping was performed by the PCR (polymerase-chain reaction) method. RESULTS: The frequency distribution of L and S alleles and genotypes of SERTPR was not statistically different between MDD patients and control participants. The proportion of SERT-in2 short (s) alleles was significantly higher among MDD patients in comparison to healthy subjects (p = 0.04). CONCLUSION: "s" allele variant in the intron 2 of SERT gene could be associated with susceptibility to MDD.
Authors:
Nada Bozina; Alma Mihaljević-Peles; Marina Sagud; Miro Jakovljević; Jadranka Sertić
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Psychiatria Danubina     Volume:  18     ISSN:  0353-5053     ISO Abbreviation:  Psychiatr Danub     Publication Date:  2006 Jun 
Date Detail:
Created Date:  2006-06-28     Completed Date:  2006-10-27     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9424753     Medline TA:  Psychiatr Danub     Country:  Croatia    
Other Details:
Languages:  eng     Pagination:  83-9     Citation Subset:  IM    
Affiliation:
Clinical Institute of Laboratory Diagnosis, Clinical Hospital Centre Zagreb, Croatia. nbozina@kbc-zagreb.hr
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MeSH Terms
Descriptor/Qualifier:
Adult
Base Pairing / genetics
Chromosome Deletion
Croatia
Depressive Disorder, Major / genetics*
Female
Gene Frequency / genetics
Genetics, Population
Genotype
Haplotypes / genetics
Humans
Introns / genetics
Male
Middle Aged
Minisatellite Repeats / genetics
Mutagenesis, Insertional / genetics
Polymerase Chain Reaction
Polymorphism, Genetic / genetics*
Promoter Regions, Genetic / genetics
Serotonin Plasma Membrane Transport Proteins / genetics*
Chemical
Reg. No./Substance:
0/Serotonin Plasma Membrane Transport Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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