| Serotonin transporter genotype x construction stress interaction in rats. | |
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MedLine Citation:
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PMID: 21549766 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A well-known example for gene x environment interactions in psychiatry is the one involving the low activity (s) allelic variant of the serotonin transporter (5-HTT) promoter polymorphism (5-HTTLPR) that in the context of stress increases risk for depression. In analogy, 5-HTT knockout rodents are highly responsive to early life, but also adult external stressors, albeit conflicting data have been obtained. In our study on emotion and cognition using homozygous 5-HTT knockout (5-HTT(-/-)) and wild-type (5-HTT(+/+)) rats we have been confronted with animal facility construction, which were associated with severe lifetime stress (noise and vibrations). To assess the impact of construction stress on well-established 5-HTT(-/-) rat phenotypes we conducted ad hoc analyses of 5-HTT(-/-) and 5-HTT(+/+) rats that grew up before and during the construction. The reproductive capacity of the parents of the experimental 5-HTT(+/-) rats was significantly decreased. Further, 5-HTT(-/-) anxiety-related phenotypes in the elevated plus maze and social interaction tests were abolished after construction noise exposure, due to increased anxiety in 5-HTT(+/+) rats and decreased anxiety in 5-HTT(-/-) rats (social interaction test only). In addition, reversal learning was improved in 5-HTT(+/+) and, to a milder extent, decreased in 5-HTT(-/-) rats. Finally, construction stress genotype-independently increased behavioural despair in the forced swim test. In conclusion, severe construction stress induces 5-HTT genotype-dependent 'for-better-and-for-worse' effects. These data importantly contribute to the understanding of 5-HTT gene x environment interactions and show the risk of losing genotype effects by construction stress. |
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Authors:
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Pieter Schipper; Lourens J P Nonkes; Peter Karel; Amanda J Kiliaan; Judith R Homberg |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2011-04-27 |
Journal Detail:
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Title: Behavioural brain research Volume: 223 ISSN: 1872-7549 ISO Abbreviation: Behav. Brain Res. Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-06-09 Completed Date: 2011-10-18 Revised Date: 2012-01-31 |
Medline Journal Info:
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Nlm Unique ID: 8004872 Medline TA: Behav Brain Res Country: Netherlands |
Other Details:
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Languages: eng Pagination: 169-75 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Elsevier B.V. All rights reserved. |
Affiliation:
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Department of Anatomy, Donders Institute for Brain, Cognition, and Behavior, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Conditioning, Classical / physiology Facility Design and Construction* Female Gene Knockout Techniques Genotype Immobility Response, Tonic / physiology Interpersonal Relations Male Maze Learning / physiology Motor Activity / physiology Rats Rats, Wistar Reversal Learning / physiology Serotonin Plasma Membrane Transport Proteins / genetics*, physiology Stress, Psychological / genetics, physiopathology* |
| Chemical | |
Reg. No./Substance:
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0/Serotonin Plasma Membrane Transport Proteins |
| Comments/Corrections | |
Erratum In:
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Behav Brain Res. 2012 Feb 1;227(1):310 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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