Document Detail

Serotonin transporter genotype (5-HTTLPR): effects of neutral and undefined conditions on amygdala activation.
MedLine Citation:
PMID:  17157270     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: A polymorphism of the human serotonin transporter gene (SCL6A4) has been associated with serotonin transporter expression and with processing of aversive stimuli in the amygdala. Functional imaging studies show that during the presentation of aversive versus neutral cues, healthy carriers of the short (s) allele showed stronger amygdala activation than long (l) carriers. However, a recent report suggested that this interaction is driven by amygdala deactivation during presentation of neutral stimuli in s carriers. METHODS: Functional MRI was used to assess amygdala activation during the presentation of a fixation cross or affectively aversive or neutral visual stimuli in 29 healthy men. RESULTS: Amygdala activation was increased in s carriers during undefined states such as the presentation of a fixation cross compared with emotionally neutral conditions. CONCLUSIONS: This finding suggests that s carriers show stronger amygdala reactivity to stimuli and contexts that are relatively uncertain, which we propose are stressful.
Andreas Heinz; Michael N Smolka; Dieter F Braus; Jana Wrase; Anne Beck; Herta Flor; Karl Mann; Gunter Schumann; Christian Büchel; Ahmad R Hariri; Daniel R Weinberger
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-12-06
Journal Detail:
Title:  Biological psychiatry     Volume:  61     ISSN:  0006-3223     ISO Abbreviation:  Biol. Psychiatry     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-04-02     Completed Date:  2007-06-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0213264     Medline TA:  Biol Psychiatry     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1011-4     Citation Subset:  IM    
Department of Psychiatry, Charité University Medicine Berlin, Campus Charité Mitte, Germany.
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MeSH Terms
Amygdala / blood supply,  physiology*
Emotions / physiology*
Functional Laterality
Gene Frequency
Image Processing, Computer-Assisted / methods
Magnetic Resonance Imaging / methods
Middle Aged
Oxygen / blood
Photic Stimulation
Polymorphism, Genetic
Serotonin Plasma Membrane Transport Proteins / genetics*
Reg. No./Substance:
0/Serotonin Plasma Membrane Transport Proteins; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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