Document Detail


Serotonin transporter gene variation and refractory mesial temporal epilepsy with hippocampal sclerosis.
MedLine Citation:
PMID:  19375285     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We performed a molecular epidemiology study in a population of 105 mesial temporal lobe epilepsy with hippocampal sclerosis (MTE-HS) patients in order to investigate the role of a polymorphism in the serotonin transporter gene (SLC6A4) in the prediction of antiepileptic drug (AED) treatment response. Homozygous carriers of the 12-repeat allele had an almost fourfold increase in risk for a MTE-HS not responding to medical treatment (OR 3.88; CI 95% 1.40-10.7; p=0.006) compared to carriers of the 10-repeat allele. Therefore, a polymorphism of SLC6A4 might be a genetic marker of pharmacoresistance in MTE-HS patients.
Authors:
Marcelo Andrés Kauffman; Damián Consalvo; Dolores Gonzalez-Morón; Florencia Aguirre; Luciana D'Alessio; Silvia Kochen
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Publication Detail:
Type:  Journal Article     Date:  2009-04-16
Journal Detail:
Title:  Epilepsy research     Volume:  85     ISSN:  1872-6844     ISO Abbreviation:  Epilepsy Res.     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-07-21     Completed Date:  2009-09-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8703089     Medline TA:  Epilepsy Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  231-4     Citation Subset:  IM    
Affiliation:
Centro de Epilepsia, División Neurología, Hospital Ramos Mejía, CEFYBO, CONICET, Buenos Aires, Argentina. marcelokauffman@marcelokauffman.info
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MeSH Terms
Descriptor/Qualifier:
Adult
Alleles
Anticonvulsants / therapeutic use
Drug Resistance
Epilepsy, Temporal Lobe / genetics*,  pathology*
Female
Genetic Variation / genetics*
Genotype
Hippocampus / pathology*
Humans
Introns / genetics
Male
Minisatellite Repeats / genetics
Risk
Sclerosis
Serotonin Plasma Membrane Transport Proteins / genetics*
Chemical
Reg. No./Substance:
0/Anticonvulsants; 0/SLC6A4 protein, human; 0/Serotonin Plasma Membrane Transport Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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