| Serotonin transporter gene polymorphism (5-HTTLPR), environmental conditions, and developing negative emotionality and fear in early childhood. | |
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MedLine Citation:
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PMID: 19137235 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Studies on neural and behavioral correlates of the serotonin transporter gene polymorphism (5-HTTLPR) strongly suggested interaction effects between the 5-HTTLPR genotype and environmental conditions on infant emotionality development. However, empirical studies that involve human infants are rare. The present study thus analyzed the interaction of the 5-HTTLPR genotype with the quality of maternal parenting behavior on the development of negative emotionality and fear in infancy. In a sample of 69 healthy firstborn infants, negative emotionality and fear were assessed at 4, 8, and 12 months using a multi-method approach. The quality of previous parenting has been operationalized as the quality of the mother-infant attachment relationship measured by the strange situation procedure at 18 months. Corresponding to hypotheses, to their caregiver insecurely attached infants who were homozygous for the s-variant of the 5-HTTLPR genotype developed a high level of negative emotionality and fear. The results thus are in line with the experimental results in the non-human primate model and point to a more pronounced susceptibility of s/s carrying infants to early rearing experiences. |
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Authors:
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Ursula Pauli-Pott; Susann Friedel; Susann Friedl; Anke Hinney; Johannes Hebebrand |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-01-10 |
Journal Detail:
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Title: Journal of neural transmission (Vienna, Austria : 1996) Volume: 116 ISSN: 1435-1463 ISO Abbreviation: J Neural Transm Publication Date: 2009 Apr |
Date Detail:
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Created Date: 2009-04-17 Completed Date: 2009-06-09 Revised Date: 2009-10-05 |
Medline Journal Info:
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Nlm Unique ID: 9702341 Medline TA: J Neural Transm Country: Austria |
Other Details:
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Languages: eng Pagination: 503-12 Citation Subset: IM |
Affiliation:
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Department of Medical Psychology, Faculty of Medicine, University of Giessen, Friedrichstrasse 36, 35392, Giessen, Germany. ursula.pauli-pott@psycho.med.uni-giessen.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Child Development* Emotions* Environment Fear* Female Humans Infant Infant Behavior Male Maternal Behavior* Mother-Child Relations Polymorphism, Genetic Sequence Analysis, DNA Serotonin Plasma Membrane Transport Proteins / genetics* |
| Chemical | |
Reg. No./Substance:
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0/SLC6A4 protein, human; 0/Serotonin Plasma Membrane Transport Proteins |
| Comments/Corrections | |
Erratum In:
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J Neural Transm. 2009 Sep;116(9):1191 Note: Friedl, Susann [corrected to Friedel, Susann] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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