Document Detail


Serotonin transporter: gene, genetic disorders, and pharmacogenetics.
MedLine Citation:
PMID:  15087484     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The highly evolutionarily conserved serotonin transporter (SERT) regulates the entire serotoninergic system and its receptors via modulation of extracellular fluid serotonin concentrations. Differences in SERT expression and function produced by three SERT genes and their variants show associations with multiple human disorders. Screens of DNA from patients with autism, ADHD, bipolar disorder, and Tourette's syndrome have detected signals in the chromosome 17q region where SERT is located. Parallel investigations of SERT knockout mice have uncovered multiple phenotypes that identify SERT as a candidate gene for additional human disorders ranging from irritable bowel syndrome to obesity. Replicated studies have demonstrated that the SERT 5'-flanking region polymorphism SS genotype is associated with poorer therapeutic responses and more frequent serious side effects during treatment with antidepressant SERT antagonists, namely, the serotonin reuptake inhibitors (SRIs).
Authors:
Dennis L Murphy; Alicja Lerner; Gary Rudnick; Klaus-Peter Lesch
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Molecular interventions     Volume:  4     ISSN:  1543-2548     ISO Abbreviation:  Mol. Interv.     Publication Date:  2004 Apr 
Date Detail:
Created Date:  2004-04-16     Completed Date:  2008-03-24     Revised Date:  2009-06-22    
Medline Journal Info:
Nlm Unique ID:  101093789     Medline TA:  Mol Interv     Country:  United States    
Other Details:
Languages:  eng     Pagination:  109-23     Citation Subset:  IM    
Affiliation:
Laboratory of Clinical Science, Building 10, Room 3D41, 10 Center Drive, MSC 1264, NIMH, NIH, Bethesda, MD 20892, USA. murphyd@intra.nimh.nih.gov
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Sequence
Animals
Brain / anatomy & histology,  metabolism
Evolution, Molecular
Genetic Diseases, Inborn*
Genetic Predisposition to Disease
Humans
Molecular Sequence Data
Nervous System Diseases* / drug therapy,  genetics,  physiopathology
Pharmacogenetics*
Polymorphism, Genetic
Positron-Emission Tomography
Sequence Alignment
Sequence Homology, Amino Acid
Serotonin / metabolism
Serotonin Plasma Membrane Transport Proteins* / chemistry,  genetics,  metabolism
Serotonin Uptake Inhibitors / adverse effects,  metabolism,  therapeutic use
Tomography, Emission-Computed, Single-Photon
Chemical
Reg. No./Substance:
0/Serotonin Plasma Membrane Transport Proteins; 0/Serotonin Uptake Inhibitors; 50-67-9/Serotonin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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