Document Detail


Serotonin transporter activity of imidazolidine-2,4-dione and imidazo[2,1-f]purine-2,4-dione derivatives in aspect of their acid-base properties.
MedLine Citation:
PMID:  23049232     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Affinities of arylpiperazinylalkyl derivatives of imidazo[2,1-f]purine-2,4-dione and imidazolidine-2,4-dione for serotonin transporter and their acid-base properties were evaluated. The dissociation constant (pK(a)) of compounds 1-22 were determinated by potentiometric titration and calculated using pKalc 3.1 module of the Pallas system. The data from experimental methods and computational calculations were compared and suitable conclusions were reached.
Authors:
Agnieszka Zagórska; Anna Czopek; Maciej Pawłowski; Małgorzata Dybała; Agata Siwek; Gabriel Nowak
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-11-19
Journal Detail:
Title:  Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents     Volume:  21     ISSN:  1054-2523     ISO Abbreviation:  Med Chem Res     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-10-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9211347     Medline TA:  Med Chem Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  3455-3459     Citation Subset:  -    
Affiliation:
Department of Pharmaceutical Chemistry, Jagiellonian University Medical College, Medyczna 9 St, 30-688 Kraków, Poland.
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