| Serotonin transporter activity of imidazolidine-2,4-dione and imidazo[2,1-f]purine-2,4-dione derivatives in aspect of their acid-base properties. | |
| | |
MedLine Citation:
|
PMID: 23049232 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Affinities of arylpiperazinylalkyl derivatives of imidazo[2,1-f]purine-2,4-dione and imidazolidine-2,4-dione for serotonin transporter and their acid-base properties were evaluated. The dissociation constant (pK(a)) of compounds 1-22 were determinated by potentiometric titration and calculated using pKalc 3.1 module of the Pallas system. The data from experimental methods and computational calculations were compared and suitable conclusions were reached. |
| | |
Authors:
|
Agnieszka Zagórska; Anna Czopek; Maciej Pawłowski; Małgorzata Dybała; Agata Siwek; Gabriel Nowak |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-11-19 |
Journal Detail:
|
Title: Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents Volume: 21 ISSN: 1054-2523 ISO Abbreviation: Med Chem Res Publication Date: 2012 Nov |
Date Detail:
|
Created Date: 2012-10-10 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9211347 Medline TA: Med Chem Res Country: - |
Other Details:
|
Languages: ENG Pagination: 3455-3459 Citation Subset: - |
Affiliation:
|
Department of Pharmaceutical Chemistry, Jagiellonian University Medical College, Medyczna 9 St, 30-688 Kraków, Poland. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: A Longitudinal Analysis of Cumulative Risks, Cumulative Promotive Factors, and Adolescent Violent Be...
Next Document: Effect of l-phenylalanine on PAL activity and production of naphthoquinone pigments in suspension cu...