| Serotonin targets the DAF-16/FOXO signaling pathway to modulate stress responses. | |
| | |
MedLine Citation:
|
PMID: 17141627 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Stress response is a fundamental form of behavioral and physiological plasticity. Here we describe how serotonin (5HT) governs stress behavior by regulating DAF-2 insulin/IGF-1 receptor signaling to the DAF-16/FOXO transcription factor at the nexus of development, metabolism, immunity, and stress responses in C. elegans. Serotonin-deficient tph-1 mutants, like daf-2 mutants, exhibit DAF-16 nuclear accumulation and constitutive physiological stress states. Exogenous 5HT and fluoxetine (Prozac) prevented DAF-16 nuclear accumulation in wild-type animals under stresses. Genetic analyses imply that DAF-2 is a downstream target of 5HT signaling and that distinct serotonergic neurons act through distinct 5HT receptors to influence distinct DAF-16-mediated stress responses. We suggest that modulation of FOXO by 5HT represents an ancient feature of stress physiology and that the C. elegans is a genetically tractable model that can be used to delineate the molecular mechanisms and drug actions linking 5HT, neuroendocrine signaling, immunity, and mitochondrial function. |
| | |
Authors:
|
Bin Liang; Mustapha Moussaif; Chih-Jen Kuan; J Jay Gargus; Ji Ying Sze |
Related Documents
:
|
9309317 - Differential expression of mitochondrial nadh dehydrogenase in ethanol-treated rat brai... 8687407 - Biogenesis of thermogenic mitochondria in brown adipose tissue of djungarian hamsters d... 16785027 - Involvement of protein kinase c delta in the alteration of mitochondrial mass in human ... 11029287 - Tom20-mediated mitochondrial protein import in muscle cells during differentiation. 9813137 - Expression of seizure-related ptz-17 is induced by potassium deprivation in cerebellar ... 23512787 - Neuroprotective effects of puerarin on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine ind... |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
|
Title: Cell metabolism Volume: 4 ISSN: 1550-4131 ISO Abbreviation: Cell Metab. Publication Date: 2006 Dec |
Date Detail:
|
Created Date: 2006-12-04 Completed Date: 2007-02-02 Revised Date: 2009-11-19 |
Medline Journal Info:
|
Nlm Unique ID: 101233170 Medline TA: Cell Metab Country: United States |
Other Details:
|
Languages: eng Pagination: 429-40 Citation Subset: IM |
Affiliation:
|
Department of Anatomy & Neurobiology, School of Medicine, University of California, Irvine, Irvine, California 92697, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Active Transport, Cell Nucleus
/
genetics Animals Animals, Genetically Modified Caenorhabditis elegans / genetics, metabolism* Caenorhabditis elegans Proteins / genetics, metabolism* Cell Nucleus / genetics, metabolism Fluoxetine / pharmacology Forkhead Transcription Factors / genetics, metabolism Models, Animal Mutation Neurons / metabolism* Neurosecretory Systems / metabolism Receptor, IGF Type 1 / genetics, immunology Receptor, Insulin / genetics, metabolism Serotonin / genetics, metabolism* Serotonin Uptake Inhibitors / pharmacology Signal Transduction* / drug effects Transcription Factors / genetics, metabolism* |
| Chemical | |
Reg. No./Substance:
|
0/Caenorhabditis elegans Proteins; 0/DAF-2 protein, C elegans; 0/Forkhead Transcription Factors; 0/Serotonin Uptake Inhibitors; 0/Transcription Factors; 0/daf-16 protein, C elegans; 50-67-9/Serotonin; 54910-89-3/Fluoxetine; EC 2.7.10.1/Receptor, IGF Type 1; EC 2.7.10.1/Receptor, Insulin |
| Comments/Corrections | |
Comment In:
|
Cell Metab. 2006 Dec;4(6):415-7
[PMID:
17141622
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: To be or NUCB2, is nesfatin the answer?
Next Document: ATF4 mediation of NF1 functions in osteoblast reveals a nutritional basis for congenital skeletal dy...