| Serotonin syndrome triggered by a single dose of suboxone. | |
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MedLine Citation:
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PMID: 18774063 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Suboxone (buprenorphine/naloxone) is an oral medication used for the treatment of opiate dependence. Because of its mixed properties at the opiate receptors, buprenorphine has a ceiling on its euphoric effects. We report the first case of serotonin syndrome caused by buprenorphine and review other medications implicated in serotonin syndrome. A 54-year-old man on tricyclic antidepressants took an unprescribed dose of buprenorphine/naloxone. He presented to the emergency department with signs and symptoms of severe serotonin syndrome including clonus, agitation, and altered mental status. His agitation was not controlled with benzodiazepines and was electively intubated. At the recommendation of the toxicology service, cyproheptadine, a serotonin receptor antagonist, was administered with improvement in the patient's symptoms. Emergency physicians should be aware of the potential of buprenorphine/naloxone to trigger serotonin syndrome. |
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Authors:
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Derek Isenberg; Stella C Wong; John A Curtis |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: The American journal of emergency medicine Volume: 26 ISSN: 1532-8171 ISO Abbreviation: Am J Emerg Med Publication Date: 2008 Sep |
Date Detail:
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Created Date: 2008-09-08 Completed Date: 2008-09-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8309942 Medline TA: Am J Emerg Med Country: United States |
Other Details:
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Languages: eng Pagination: 840.e3-5 Citation Subset: IM |
Affiliation:
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Department of Emergency Medicine, Drexel University College of Medicine, Philadelphia, PA 19102, USA. disenber@drexelmed.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Buprenorphine
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adverse effects* Cyproheptadine / therapeutic use Humans Male Middle Aged Naloxone / adverse effects* Narcotic Antagonists / adverse effects* Serotonin Antagonists / therapeutic use Serotonin Syndrome / chemically induced*, drug therapy, physiopathology* |
| Chemical | |
Reg. No./Substance:
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0/Narcotic Antagonists; 0/Serotonin Antagonists; 0/suboxone; 129-03-3/Cyproheptadine; 465-65-6/Naloxone; 52485-79-7/Buprenorphine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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