| Serotonin syndrome secondary to phenelzine-venlafaxine interaction. | |
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MedLine Citation:
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PMID: 9545162 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A 44-year-old woman accidentally ingested phenelzine along with venlafaxine. Thirty minutes after the ingestion the woman began to feel nauseous and anxious. Approximately 45 minutes later a friend noted that the woman had lower extremity shaking and increasingly rapid respirations. The friend brought the woman to the emergency department and she was subsequently diagnosed with serotonin syndrome. Serotonin syndrome is usually precipitated by combinations of serotonin-potentiating agents and can lead to devastating outcomes. When using combinations of drugs that elevate serotonin levels in the central nervous system, the possibility of serotonin syndrome should be considered. |
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Authors:
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L A Weiner; M Smythe; J Cisek |
Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Pharmacotherapy Volume: 18 ISSN: 0277-0008 ISO Abbreviation: Pharmacotherapy Publication Date: 1998 Mar-Apr |
Date Detail:
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Created Date: 1998-05-29 Completed Date: 1998-05-29 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8111305 Medline TA: Pharmacotherapy Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 399-403 Citation Subset: IM |
Affiliation:
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Department of Pharmacy Practice, Wayne State University, Detroit, Michigan, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antidepressive Agents / administration & dosage, adverse effects*, therapeutic use Central Nervous System / chemistry Central Nervous System Diseases / chemically induced Cyclohexanols / administration & dosage, adverse effects*, therapeutic use Drug Interactions Female Humans Phenelzine / administration & dosage, adverse effects*, therapeutic use Serotonin / metabolism* Serotonin Uptake Inhibitors / administration & dosage, adverse effects*, therapeutic use Syndrome |
| Chemical | |
Reg. No./Substance:
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0/Antidepressive Agents; 0/Cyclohexanols; 0/Serotonin Uptake Inhibitors; 50-67-9/Serotonin; 51-71-8/Phenelzine; 93413-69-5/venlafaxine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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