| Serotonin syndrome in dextromethorphan ingestion responsive to propofol therapy. | |
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MedLine Citation:
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PMID: 18007217 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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An 18-year-old male developed a severe serotonin syndrome after recreational ingestion of Coricidin HBP (chlorpheniramine 4 mg and dextromethorphan hydrobromide 30 mg). Propofol infusion rapidly normalized his agitation, neuromuscular hyperactivity, and autonomic instability. Confirmatory analysis demonstrated a dextromethorphan serum concentration of 930 ng/mL. Dextromethorphan can produce serotonin syndrome in the absence of another serotonergic drug. |
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Authors:
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Michael Ganetsky; Kavita M Babu; Edward W Boyer |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Pediatric emergency care Volume: 23 ISSN: 1535-1815 ISO Abbreviation: Pediatr Emerg Care Publication Date: 2007 Nov |
Date Detail:
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Created Date: 2007-11-16 Completed Date: 2007-12-14 Revised Date: 2010-07-27 |
Medline Journal Info:
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Nlm Unique ID: 8507560 Medline TA: Pediatr Emerg Care Country: United States |
Other Details:
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Languages: eng Pagination: 829-31 Citation Subset: IM |
Affiliation:
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Division of Medical Toxicology, Department of Emergency Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA. mganetsky@comcast.net |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetaminophen
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adverse effects*,
blood Adolescent Algorithms Chlorpheniramine / adverse effects*, blood Dextromethorphan / adverse effects*, blood Drug Combinations Humans Hypnotics and Sedatives / therapeutic use* Infusions, Intravenous Male Overdose Phenylpropanolamine / adverse effects*, blood Propofol / therapeutic use* Serotonin Syndrome / chemically induced*, diagnosis, drug therapy* Substance-Related Disorders / complications |
| Chemical | |
Reg. No./Substance:
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0/Drug Combinations; 0/Hypnotics and Sedatives; 0/acetaminophen, chlorpheniramine, dextromethorphan, phenylpropanolamine drug combination; 103-90-2/Acetaminophen; 125-71-3/Dextromethorphan; 132-22-9/Chlorpheniramine; 14838-15-4/Phenylpropanolamine; 2078-54-8/Propofol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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