| Serotonin signaling in diverticular disease. | |
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MedLine Citation:
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PMID: 18491196 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Diverticulosis is extremely common in Western societies and is associated with complications in up to 15%of cases. Altered motility is an important feature of the pathogenesis of diverticular disease, and serotonin (5-HT) release is a primary trigger of gut motility. This study aims to determine whether colonic 5-HT signaling is altered in patients with diverticulosis or diverticulitis, and whether differences in serotonin signaling may distinguish patients with asymptomatic diverticulosis from those who develop disease specific complications. Sigmoid colon biopsies were obtained from healthy control subjects, individuals with asymptomatic diverticulosis, and those with a history of CT-proven diverticulitis within the preceding 6 months. The key elements of 5-HT signaling including content, release, and 5-HT transporter (SERT) expression were analyzed. A significant decrease in SERT transcript levels was present in the mucosa of patients with a history of diverticulitis when compared with controls, but not in those with asymptomatic diverticulosis. Mucosal 5-HT content, enterochromaffin (EC) cell numbers, and TpH-1 mRNA levels were comparable amongst the groups, as were basal and stimulated 5-HT release. Alterations in 5-HT signaling do not appear to be responsible for the development of diverticula. However, patients with a recent history of acute diverticulitis have a significant attenuation in SERT expression and function, likely secondary to previous inflammation. Our findings may explain the persistent symptoms of pain and altered motility so often observed in patients with diverticulitis long after recovery from the acute inflammatory response. |
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Authors:
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Meagan M Costedio; Matthew D Coates; Amy B Danielson; Thomas R Buttolph; Hagen J Blaszyk; Gary M Mawe; Neil H Hyman |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2008-05-20 |
Journal Detail:
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Title: Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract Volume: 12 ISSN: 1873-4626 ISO Abbreviation: J. Gastrointest. Surg. Publication Date: 2008 Aug |
Date Detail:
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Created Date: 2008-07-31 Completed Date: 2008-10-23 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 9706084 Medline TA: J Gastrointest Surg Country: United States |
Other Details:
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Languages: eng Pagination: 1439-45 Citation Subset: IM |
Affiliation:
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Department of Surgery, University of Vermont College of Medicine, Burlington, VT 05405, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Biopsy Colon, Sigmoid* Diverticulitis, Colonic / genetics, metabolism*, pathology Female Follow-Up Studies Gene Expression* Humans Immunohistochemistry Intestinal Mucosa / metabolism, pathology Male Middle Aged RNA, Messenger / genetics* Retrospective Studies Reverse Transcriptase Polymerase Chain Reaction Serotonin / metabolism* Serotonin Plasma Membrane Transport Proteins / biosynthesis, genetics* Signal Transduction / genetics* |
| Grant Support | |
ID/Acronym/Agency:
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DK62267/DK/NIDDK NIH HHS; P20 RR16435/RR/NCRR NIH HHS; R01 DK062267-03S1/DK/NIDDK NIH HHS; R01 DK062267-04A2/DK/NIDDK NIH HHS; R01 DK062267-05/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/RNA, Messenger; 0/SLC6A4 protein, human; 0/Serotonin Plasma Membrane Transport Proteins; 50-67-9/Serotonin |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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