Document Detail

Serotonin reuptake inhibitors are associated with reduced severity of ictal hypoxemia in medically refractory partial epilepsy.
MedLine Citation:
PMID:  20491872     Owner:  NLM     Status:  MEDLINE    
Ictal respiratory dysfunction occurs in patients with epilepsy and may contribute to sudden unexplained death in epilepsy (SUDEP). Fluoxetine reverses respiratory arrest in a mouse model of epilepsy, suggesting that selective serotonin reuptake inhibitors (SSRIs) may reduce ictal respiratory dysfunction. Video–electroencephalography (EEG) and pulse oximetry data from 496 seizures in 73 consecutive patients with partial epilepsy was reviewed, including 87 seizures in 16 patients taking SSRIs (SSRI+) and 409 seizures in 57 patients not taking SSRIs (SSRI)). The proportion of ictal-related oxygen desaturation <85% with partial seizures without secondary convulsions in SSRI+ patients was reduced relative to SSRI) patients (p = 0.011). There was no statistically significant difference in ictal oxygen desaturation for secondarily generalized convulsions. SSRIs are associated with reduced likelihood of ictal oxygen desaturation in patients with partial seizures.
Lisa M Bateman; Chin-Shang Li; Tzu-Chun Lin; Masud Seyal
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Epilepsia     Volume:  51     ISSN:  1528-1167     ISO Abbreviation:  Epilepsia     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-11-10     Completed Date:  2010-12-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2983306R     Medline TA:  Epilepsia     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2211-4     Citation Subset:  IM    
Department of Neurology, Division of Biostatistics, University of California, Davis, California, USA.
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MeSH Terms
Aged, 80 and over
Anoxia / chemically induced*,  diagnosis,  epidemiology*
Anticonvulsants / therapeutic use
Drug Resistance
Electroencephalography / statistics & numerical data*
Epilepsies, Partial / drug therapy*,  metabolism
Middle Aged
Retrospective Studies
Serotonin Uptake Inhibitors / adverse effects*,  therapeutic use*
Severity of Illness Index
Telemetry / statistics & numerical data
Grant Support
Reg. No./Substance:
0/Anticonvulsants; 0/Serotonin Uptake Inhibitors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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