| Serotonin reuptake inhibitors are associated with reduced severity of ictal hypoxemia in medically refractory partial epilepsy. | |
MedLine Citation:
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PMID: 20491872 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Ictal respiratory dysfunction occurs in patients with epilepsy and may contribute to sudden unexplained death in epilepsy (SUDEP). Fluoxetine reverses respiratory arrest in a mouse model of epilepsy, suggesting that selective serotonin reuptake inhibitors (SSRIs) may reduce ictal respiratory dysfunction. Video–electroencephalography (EEG) and pulse oximetry data from 496 seizures in 73 consecutive patients with partial epilepsy was reviewed, including 87 seizures in 16 patients taking SSRIs (SSRI+) and 409 seizures in 57 patients not taking SSRIs (SSRI)). The proportion of ictal-related oxygen desaturation <85% with partial seizures without secondary convulsions in SSRI+ patients was reduced relative to SSRI) patients (p = 0.011). There was no statistically significant difference in ictal oxygen desaturation for secondarily generalized convulsions. SSRIs are associated with reduced likelihood of ictal oxygen desaturation in patients with partial seizures. |
Authors:
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Lisa M Bateman; Chin-Shang Li; Tzu-Chun Lin; Masud Seyal |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Epilepsia Volume: 51 ISSN: 1528-1167 ISO Abbreviation: Epilepsia Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-11-10 Completed Date: 2010-12-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 2983306R Medline TA: Epilepsia Country: United States |
Other Details:
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Languages: eng Pagination: 2211-4 Citation Subset: IM |
Affiliation:
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Department of Neurology, Division of Biostatistics, University of California, Davis, California, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Aged, 80 and over Anoxia / chemically induced*, diagnosis, epidemiology* Anticonvulsants / therapeutic use Drug Resistance Electroencephalography / statistics & numerical data* Epilepsies, Partial / drug therapy*, metabolism Female Humans Male Middle Aged Retrospective Studies Serotonin Uptake Inhibitors / adverse effects*, therapeutic use* Severity of Illness Index Telemetry / statistics & numerical data |
| Grant Support | |
ID/Acronym/Agency:
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UL1 RR024146/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Anticonvulsants; 0/Serotonin Uptake Inhibitors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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