| Serotonin reuptake blockers in vitro and in vivo. | |
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MedLine Citation:
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PMID: 2828437 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Agents that inhibit selectively the neuronal reuptake of serotonin but not catecholamines, and that do not interact directly with neurotransmitter receptors, can have antidepressant activity clinically. Their antidepressant action presumably is initiated by enhanced serotonergic input to other neuronal systems in brain, which leads to primary and secondary (adaptive) changes in neurotransmission and results in remission of depressive symptoms. |
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Authors:
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R W Fuller; D T Wong |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Journal of clinical psychopharmacology Volume: 7 ISSN: 0271-0749 ISO Abbreviation: J Clin Psychopharmacol Publication Date: 1987 Dec |
Date Detail:
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Created Date: 1988-03-18 Completed Date: 1988-03-18 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 8109496 Medline TA: J Clin Psychopharmacol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 36S-43S Citation Subset: IM |
Affiliation:
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Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Brain / drug effects, metabolism* Humans Receptors, Neurotransmitter / metabolism Serotonin / metabolism* Serotonin Antagonists / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Neurotransmitter; 0/Serotonin Antagonists; 50-67-9/Serotonin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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