Document Detail

Serotonin reuptake blockers in vitro and in vivo.
MedLine Citation:
PMID:  2828437     Owner:  NLM     Status:  MEDLINE    
Agents that inhibit selectively the neuronal reuptake of serotonin but not catecholamines, and that do not interact directly with neurotransmitter receptors, can have antidepressant activity clinically. Their antidepressant action presumably is initiated by enhanced serotonergic input to other neuronal systems in brain, which leads to primary and secondary (adaptive) changes in neurotransmission and results in remission of depressive symptoms.
R W Fuller; D T Wong
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of clinical psychopharmacology     Volume:  7     ISSN:  0271-0749     ISO Abbreviation:  J Clin Psychopharmacol     Publication Date:  1987 Dec 
Date Detail:
Created Date:  1988-03-18     Completed Date:  1988-03-18     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8109496     Medline TA:  J Clin Psychopharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  36S-43S     Citation Subset:  IM    
Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285.
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MeSH Terms
Brain / drug effects,  metabolism*
Receptors, Neurotransmitter / metabolism
Serotonin / metabolism*
Serotonin Antagonists / pharmacology*
Reg. No./Substance:
0/Receptors, Neurotransmitter; 0/Serotonin Antagonists; 50-67-9/Serotonin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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