Document Detail


Serotonin and pulmonary hypertension--from bench to bedside?
MedLine Citation:
PMID:  19286424     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The serotonin hypothesis of pulmonary arterial hypertension (PAH) arose owing to anorexigens, acting as indirect serotinergic agonists, causing PAH. However, it is now thought that serotonin plays an important role in the pathobiology of PAH per se. The rate-limiting enzyme in the synthesis of peripheral serotonin is tryptophan hydroxylase 1 (TPH1), serotonin can mediate pulmonary arterial smooth muscle cell proliferation via the serotonin transporter (SERT) and serotonin can induce pulmonary vasoconstriction via the 5-HT1B receptor in man. There is evidence that TPH1, SERT and 5-HT1B expression/activity can be upregulated in clinical PAH. This review discusses recent evidence implicating serotonin in the development of experimental and clinical PAH and suggests potential therapeutic targets.
Authors:
Margaret R MacLean; Yvonne Dempsie
Related Documents :
239294 - Reversal of pulmonary circulation.
3721494 - Medial defects of lung vessels: a new cause of pulmonary hypertension.
15897644 - Long-term clinical course of a patient with anti pl-12 antibody accompanied by intersti...
18383374 - Pulmonary capillary endothelial metabolic dysfunction: severity in pulmonary arterial h...
22356024 - Pulmonary functions in patients with subclinical hypothyroidism.
19356494 - Detection of lipid core coronary plaques in autopsy specimens with a novel catheter-bas...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2009-03-13
Journal Detail:
Title:  Current opinion in pharmacology     Volume:  9     ISSN:  1471-4892     ISO Abbreviation:  Curr Opin Pharmacol     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-06-01     Completed Date:  2009-08-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100966133     Medline TA:  Curr Opin Pharmacol     Country:  England    
Other Details:
Languages:  eng     Pagination:  281-6     Citation Subset:  IM    
Affiliation:
Integrative and Systems Biology, Faculty of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK. m.maclean@bio.gla.ac.uk
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Drug Delivery Systems
Humans
Hypertension, Pulmonary / etiology,  genetics,  physiopathology*
Muscle, Smooth, Vascular / metabolism
Pulmonary Artery / metabolism
Receptor, Serotonin, 5-HT1B / genetics,  metabolism*
Serotonin / metabolism*
Serotonin Agonists / adverse effects
Serotonin Plasma Membrane Transport Proteins / genetics,  metabolism
Tryptophan Hydroxylase / genetics,  metabolism
Up-Regulation
Vasoconstriction
Grant Support
ID/Acronym/Agency:
//Biotechnology and Biological Sciences Research Council; //British Heart Foundation
Chemical
Reg. No./Substance:
0/Receptor, Serotonin, 5-HT1B; 0/Serotonin Agonists; 0/Serotonin Plasma Membrane Transport Proteins; 50-67-9/Serotonin; EC 1.14.16.4/TPH1 protein, human; EC 1.14.16.4/Tryptophan Hydroxylase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Inhaled muscarinic antagonists for COPD-does an anti-inflammatory mechanism really play a role?
Next Document:  Lymphocyte kinetics in health and disease.