Document Detail

Serotonin and pulmonary hypertension--from bench to bedside?
MedLine Citation:
PMID:  19286424     Owner:  NLM     Status:  MEDLINE    
The serotonin hypothesis of pulmonary arterial hypertension (PAH) arose owing to anorexigens, acting as indirect serotinergic agonists, causing PAH. However, it is now thought that serotonin plays an important role in the pathobiology of PAH per se. The rate-limiting enzyme in the synthesis of peripheral serotonin is tryptophan hydroxylase 1 (TPH1), serotonin can mediate pulmonary arterial smooth muscle cell proliferation via the serotonin transporter (SERT) and serotonin can induce pulmonary vasoconstriction via the 5-HT1B receptor in man. There is evidence that TPH1, SERT and 5-HT1B expression/activity can be upregulated in clinical PAH. This review discusses recent evidence implicating serotonin in the development of experimental and clinical PAH and suggests potential therapeutic targets.
Margaret R MacLean; Yvonne Dempsie
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2009-03-13
Journal Detail:
Title:  Current opinion in pharmacology     Volume:  9     ISSN:  1471-4892     ISO Abbreviation:  Curr Opin Pharmacol     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-06-01     Completed Date:  2009-08-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100966133     Medline TA:  Curr Opin Pharmacol     Country:  England    
Other Details:
Languages:  eng     Pagination:  281-6     Citation Subset:  IM    
Integrative and Systems Biology, Faculty of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK.
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MeSH Terms
Drug Delivery Systems
Hypertension, Pulmonary / etiology,  genetics,  physiopathology*
Muscle, Smooth, Vascular / metabolism
Pulmonary Artery / metabolism
Receptor, Serotonin, 5-HT1B / genetics,  metabolism*
Serotonin / metabolism*
Serotonin Agonists / adverse effects
Serotonin Plasma Membrane Transport Proteins / genetics,  metabolism
Tryptophan Hydroxylase / genetics,  metabolism
Grant Support
//Biotechnology and Biological Sciences Research Council; //British Heart Foundation
Reg. No./Substance:
0/Receptor, Serotonin, 5-HT1B; 0/Serotonin Agonists; 0/Serotonin Plasma Membrane Transport Proteins; 50-67-9/Serotonin; EC protein, human; EC Hydroxylase

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