| Serotonin modulates glutamate action in the medulla to regulate cardiovascular functions in cats. | |
| | |
MedLine Citation:
|
PMID: 16201450 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
We examined the effects of serotonin (5-HT) on cardiovascular responses and blood flows in the right common carotid artery (RCCA), superior mesenteric artery (SMA) and right femoral artery (RFA), stimulated by glutamate (Glu) in the dorsomedial medulla (DM), rostral ventrolateral medulla (RVLM) and caudal ventrolateral medulla (CVLM). Microinjection of Glu into the DM produced increases in systemic arterial pressure (SAP) and flows in the RCCA and RFA, and decrease in flow in the SMA. Microinjection of Glu into the RVLM produced increases in SAP and decreases in flows in the RCCA, SMA and RFA. Prior microinjections of 5-HT into the same sites attenuated all the Glu-induced responses. Microinjection of Glu into the CVLM produced decreases in SAP and flows in the RCCA, SMA and RFA. These decreases were potentiated by prior injection of 5-HT. These findings suggest that 5-HT modulates the cardiovascular and blood flow responses induced by Glu in the medulla. |
| | |
Authors:
|
Wun-Chin Wu; Ming-Ren Wang; Ching-Yue Yang; Chun-Kuei Su; Chok-Yung Chai |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: The Chinese journal of physiology Volume: 48 ISSN: 0304-4920 ISO Abbreviation: Chin J Physiol Publication Date: 2005 Jun |
Date Detail:
|
Created Date: 2005-10-05 Completed Date: 2005-10-21 Revised Date: 2009-08-12 |
Medline Journal Info:
|
Nlm Unique ID: 7804502 Medline TA: Chin J Physiol Country: China (Republic : 1949- ) |
Other Details:
|
Languages: eng Pagination: 65-71 Citation Subset: IM |
Affiliation:
|
Department of Electronic Engineering, National Penghu Institute of Technology, Penghu, Taiwan, ROC. wcwu@npit.edu.tw |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Blood Pressure / drug effects* Cats Dose-Response Relationship, Drug Female Glutamic Acid / pharmacology* Heart Rate / drug effects Male Medulla Oblongata / drug effects*, physiology Regional Blood Flow / drug effects Serotonin / pharmacology* |
| Chemical | |
Reg. No./Substance:
|
50-67-9/Serotonin; 56-86-0/Glutamic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Simultaneous multispecies gas sensing by use of a sampled grating distributed Bragg reflector and mo...
Next Document: Sleep dependent effect of dark pulses on sleep in albino and pigmented rats.