Document Detail


Serotonin microinfusion into the ventral tegmental area increases accumbens dopamine release.
MedLine Citation:
PMID:  2575444     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of microinfusion of serotonin (5-HT) agents as well as glutamate and muscimol into the ventral tegmental area (VTA) on dopamine (DA) release in the ipsilateral nucleus accumbens (ACC) were investigated in freely moving rats, using a push-pull perfusion procedure. The baseline values for DA, 3,4-dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA) and 5-hydroxyindoleacetic acid (5-HIAA) were approximately 0.24, 8.4, 2.1 and 2.7 pmol/15 min, respectively, in the push-pull perfusate of the ACC. When microinfused into the VTA, glutamate (0.74 microgram) significantly (p less than 0.05) increased the contents of DOPAC (110%) and HVA (90%) over baseline levels in the perfusate. On the other hand, 0.5 microgram muscimol (a gamma-amino-n-butyric acid, GABA, agonist) significantly, (p less than 0.05) decreased both DA (40%) and DOPAC (20%) levels relative to baseline values. Administration of 2 micrograms 5-HT into the VTA caused a significant (p less than 0.05) elevation in the perfusate levels of DOPAC (80%) and HVA (70%) over baseline values. A similar effect was obtained with a nonselective 5-HT1 agonist but not with a selective 5-HT1A agonist. The results suggest that 5-HT innervations in the VTA may have an excitatory action possibly via 5-HT1B rather than 5-HT1A receptors on the mesolimbic DA system projecting to the ACC and that this DA system may also be regulated by glutamatergic and GABAergic (via GABAA receptors) inputs.
Authors:
X M Guan; W J McBride
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Brain research bulletin     Volume:  23     ISSN:  0361-9230     ISO Abbreviation:  Brain Res. Bull.     Publication Date:  1989 Dec 
Date Detail:
Created Date:  1990-03-08     Completed Date:  1990-03-08     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7605818     Medline TA:  Brain Res Bull     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  541-7     Citation Subset:  IM    
Affiliation:
Department of Psychiatry, Indiana University School of Medicine, Indianapolis 46202-4887.
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MeSH Terms
Descriptor/Qualifier:
3,4-Dihydroxyphenylacetic Acid / metabolism
Animals
Dopamine / metabolism*
Functional Laterality
Glutamates / pharmacology
Glutamic Acid
Male
Muscimol / pharmacology
Nucleus Accumbens / metabolism*
Rats
Rats, Inbred Strains
Septal Nuclei / metabolism*
Serotonin / pharmacology*
Tegmentum Mesencephali / drug effects*,  metabolism
Grant Support
ID/Acronym/Agency:
AA 03243/AA/NIAAA NIH HHS
Chemical
Reg. No./Substance:
0/Glutamates; 102-32-9/3,4-Dihydroxyphenylacetic Acid; 2763-96-4/Muscimol; 50-67-9/Serotonin; 56-86-0/Glutamic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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