| Serotonin metabolism in the central nervous system in portacaval shunted rats infused with fat emulsion. | |
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MedLine Citation:
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PMID: 2926979 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Increased brain concentrations of tryptophan, and presumably thereby increased brain serotonin metabolism, have been observed following liver impairment and implicated in the etiology of portal-systemic encephalopathy (PSE). Increased plasma-free tryptophan (ie, not albumin-bound) concentrations can be expected after exogenous fat administration. This might further increase the brain serotonin metabolism in liver failure and negatively influence the PSE. We treated rats 2 weeks after end-to-side portacaval shunt (PCS) with continuous intravenous infusion of fat emulsion (Intralipid 20%) for 24 and 72 hr, respectively. The regional serotonin turnover was determined in different regions of the central nervous system (CNS) by measuring 5-hydroxyindole concentrations after NSD 1015 decarboxylase inhibition. The results revealed no further increase of the CNS serotonin turnover after fat infusion to PCS rats, compared with PCS rats given equal amounts of glucose. Thus, continuous infusion of a fat emulsion caused no major alteration of the CNS serotonin metabolism in PCS rats. |
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Authors:
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F Bengtsson; M Bugge; P Herlin; A Nobin; B Jeppsson |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: JPEN. Journal of parenteral and enteral nutrition Volume: 13 ISSN: 0148-6071 ISO Abbreviation: JPEN J Parenter Enteral Nutr Publication Date: 1989 Jan-Feb |
Date Detail:
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Created Date: 1989-05-02 Completed Date: 1989-05-02 Revised Date: 2007-02-21 |
Medline Journal Info:
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Nlm Unique ID: 7804134 Medline TA: JPEN J Parenter Enteral Nutr Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 65-70 Citation Subset: IM |
Affiliation:
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Department of Surgery, Lund University, Sweden. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Brain / metabolism* Fat Emulsions, Intravenous / metabolism* Portacaval Shunt, Surgical* Rats Rats, Inbred Strains Serotonin / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Fat Emulsions, Intravenous; 50-67-9/Serotonin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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