Document Detail


Serotonin mediates food-odor associative learning in the nematode Caenorhabditiselegans.
MedLine Citation:
PMID:  12202746     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We demonstrate that Caenorhabditis elegans is able to form an association between the presence of the odorant benzaldehyde and the food content of its environment. When exposed to 100% benzaldehyde for 1 h in the absence of food the naive attractive response is reduced, and we have found that this olfactory adaptation is attenuated by the presence of food. Contrary to nonassociative (single stimulus) learning theory, this response is not a function of the total time of exposure to benzaldehyde but rather an associative function of the ability of benzaldehyde to predict a nutrient-deficient environment. Genetic and pharmacological evidence revealed that the effects of food in this learning paradigm are mediated by serotonergic signaling.
Authors:
William M Nuttley; Karen P Atkinson-Leadbeater; Derek Van Der Kooy
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2002-08-29
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  99     ISSN:  0027-8424     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  2002 Sep 
Date Detail:
Created Date:  2002-09-18     Completed Date:  2002-10-28     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  United States    
Other Details:
Languages:  eng     Pagination:  12449-54     Citation Subset:  IM    
Affiliation:
Department of Anatomy and Cell Biology, Neurobiology Research Group, University of Toronto, Toronto, ON, Canada M5S 1A8. bill.nuttley@utoronto.ca
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MeSH Terms
Descriptor/Qualifier:
Adaptation, Physiological
Animals
Benzaldehydes
Caenorhabditis elegans / genetics,  physiology*
Chemotaxis / physiology
Food
Genes, Helminth
Learning / physiology*
Mutation
Odors
Serotonin / physiology*
Signal Transduction / genetics,  physiology
Smell / physiology
Synaptic Transmission / physiology
Tryptophan Hydroxylase / genetics,  physiology
Chemical
Reg. No./Substance:
0/Benzaldehydes; 100-52-7/benzaldehyde; 50-67-9/Serotonin; EC 1.14.16.4/Tryptophan Hydroxylase
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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