| Serotonin syndrome precipitated by fentanyl during procedural sedation. | |
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MedLine Citation:
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PMID: 18757161 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Fentanyl is frequently used for analgesia during emergency procedures. We present the cases of 2 patients who developed agitation and delirium after intravenous fentanyl administration. These patients were chronically taking selective serotonin reuptake inhibitors (SSRIs). Both developed neuromuscular examinations consistent with serotonin syndrome, a diagnosis that must be established on the basis of clinical criteria. Although they required aggressive supportive care, including mechanical ventilation, both patients made a full recovery. Use of fentanyl for procedural sedation may precipitate serotonin syndrome in patients taking SSRIs or other serotonergic drugs. |
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Authors:
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Ron Kirschner; J Ward Donovan |
Publication Detail:
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Type: Case Reports; Journal Article Date: 2008-08-30 |
Journal Detail:
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Title: The Journal of emergency medicine Volume: 38 ISSN: 0736-4679 ISO Abbreviation: J Emerg Med Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-05-10 Completed Date: 2010-09-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8412174 Medline TA: J Emerg Med Country: United States |
Other Details:
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Languages: eng Pagination: 477-80 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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PinnacleHealth Toxicology Center, Pennsylvania State University Toxicology Fellowship, Harrisburg, Pennsylvania, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Conscious Sedation
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adverse effects* Emergency Service, Hospital Female Fentanyl / adverse effects* Humans Hypnotics and Sedatives / adverse effects* Middle Aged Patient Transfer Respiration, Artificial Serotonin Syndrome / chemically induced*, therapy |
| Chemical | |
Reg. No./Substance:
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0/Hypnotics and Sedatives; 437-38-7/Fentanyl |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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