Document Detail


Serotonin Metabolism in the Placenta in Exacerbation of Herpesvirus Infection during Pregnancy.
MedLine Citation:
PMID:  23330138     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Serotonin metabolism in the blood and placental homogenate was studied in pregnancy aggravated by exacerbation of herpesvirus infection. Blood serotonin content in pregnant patients increased with increasing herpesvirus antibody titers and reduction of monoamine oxidase activity. Urinary excretion of 5-hydroxyindoleacetic acid (5-HIAA) decreased. The decrease of monoamine oxidase activity in placental homogenate led to an increase of serotonin level, which was paralleled by destruction of mitochondria in the syncytiotrophoblast, suppression of BCL-2 protein activity, and increase of caspase-3 level.
Authors:
M T Lutsenko; I A Andrievskaya
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Bulletin of experimental biology and medicine     Volume:  154     ISSN:  1573-8221     ISO Abbreviation:  Bull. Exp. Biol. Med.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2013-01-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372557     Medline TA:  Bull Exp Biol Med     Country:  United States    
Other Details:
Languages:  eng; rus     Pagination:  255-9     Citation Subset:  IM    
Affiliation:
Far-Eastern Research Center of Respiratory Physiology and Pathology, Siberian Division of the Russian Academy of Medical Sciences, Blagoveshchensk, Russia. Lucenkomt@mail.ru.
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