Document Detail

Serotonin and the GI tract.
MedLine Citation:
PMID:  19765366     Owner:  NLM     Status:  MEDLINE    
Serotonin (5-hydroxytryptamine, 5-HT) participates in several functions of the gastrointestinal tract. Receptors in seven families (5-HT(1)-5-HT(7)) were identified, many of which are present on enterocytes, intrinsic and extrinsic neurons, interstitial cells, and gut myocytes. Most 5-HT is released from enterochromaffin cells in response to physiologic and pathologic stimuli. Roles of 5-HT in health include control of normal gut motor activity, secretion, and sensation, and regulation of food intake and cell growth. Abnormalities of serotonergic function contribute to symptom genesis in functional bowel disorders, inflammatory and infectious diseases of the gut, emetic responses to varied stimuli, obesity, and dysregulation of cell growth. Therapies acting as agonists or antagonists of 5-HT receptors or that modulate 5-HT reuptake play prominent roles in managing these conditions, although use of many agents is hampered by cardiopulmonary complications. Novel agents are in testing, which may exhibit efficacy without significant toxicity.
William L Hasler
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Current gastroenterology reports     Volume:  11     ISSN:  1534-312X     ISO Abbreviation:  Curr Gastroenterol Rep     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-09-21     Completed Date:  2009-12-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100888896     Medline TA:  Curr Gastroenterol Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  383-91     Citation Subset:  IM    
Division of Gastroenterology, University of Michigan Health System, Ann Arbor, MI 48109, USA.
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MeSH Terms
Drug Therapy, Combination
Enterocytes / metabolism
Gastrointestinal Agents / therapeutic use*
Gastrointestinal Diseases / drug therapy*,  metabolism,  physiopathology*
Gastrointestinal Motility / drug effects
Gastrointestinal Tract / innervation
Receptors, Serotonin / drug effects*,  metabolism
Serotonin / metabolism*
Serotonin Agents / metabolism*
Serotonin Agonists / therapeutic use*
Serotonin Antagonists / therapeutic use*
Treatment Outcome
Reg. No./Substance:
0/Gastrointestinal Agents; 0/Receptors, Serotonin; 0/Serotonin Agents; 0/Serotonin Agonists; 0/Serotonin Antagonists; 50-67-9/Serotonin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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