| Serotonin and blood pressure regulation. | |
| | |
MedLine Citation:
|
PMID: 22407614 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
5-Hydroxytryptamine (5-HT; serotonin) was discovered more than 60 years ago as a substance isolated from blood. The neural effects of 5-HT have been well investigated and understood, thanks in part to the pharmacological tools available to dissect the serotonergic system and the development of the frequently prescribed selective serotonin-reuptake inhibitors. By contrast, our understanding of the role of 5-HT in the control and modification of blood pressure pales in comparison. Here we focus on the role of 5-HT in systemic blood pressure control. This review provides an in-depth study of the function and pharmacology of 5-HT in those tissues that can modify blood pressure (blood, vasculature, heart, adrenal gland, kidney, brain), with a focus on the autonomic nervous system that includes mechanisms of action and pharmacology of 5-HT within each system. We compare the change in blood pressure produced in different species by short- and long-term administration of 5-HT or selective serotonin receptor agonists. To further our understanding of the mechanisms through which 5-HT modifies blood pressure, we also describe the blood pressure effects of commonly used drugs that modify the actions of 5-HT. The pharmacology and physiological actions of 5-HT in modifying blood pressure are important, given its involvement in circulatory shock, orthostatic hypotension, serotonin syndrome and hypertension. |
| | |
Authors:
|
Stephanie W Watts; Shaun F Morrison; Robert Patrick Davis; Susan M Barman |
Related Documents
:
|
12638624 - Average magnitude of heartbeat fluctuations in healthy subjects after exposure to 4 hou... 7572224 - The effect of change in sympatho-vagal balance on heart rate and blood pressure variabi... 6544634 - Interactions between the autonomic nervous system and tachycardias in man. 18713324 - Heart rate variability in middle-aged men with new-onset hypertension. 3515824 - Peripheral airway pressure during high frequency ventilation. 17618134 - Evaluation of changes of systemic blood pressure and shunt incidence in cea. |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Review Date: 2012-03-08 |
Journal Detail:
|
Title: Pharmacological reviews Volume: 64 ISSN: 1521-0081 ISO Abbreviation: Pharmacol. Rev. Publication Date: 2012 Apr |
Date Detail:
|
Created Date: 2012-03-16 Completed Date: 2012-07-16 Revised Date: 2013-04-01 |
Medline Journal Info:
|
Nlm Unique ID: 0421737 Medline TA: Pharmacol Rev Country: United States |
Other Details:
|
Languages: eng Pagination: 359-88 Citation Subset: IM |
Affiliation:
|
Department of Pharmacology & Toxicology, Michigan State University, East Lansing, MI 48824-1317, USA. wattss@msu.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Blood Pressure / physiology* Humans Hypertension / physiopathology Hypotension, Orthostatic / physiopathology Receptors, Serotonin / drug effects, metabolism* Serotonin / metabolism* Serotonin Antagonists / pharmacology Serotonin Receptor Agonists / pharmacology Serotonin Syndrome / physiopathology Shock / physiopathology Species Specificity |
| Grant Support | |
ID/Acronym/Agency:
|
HL081115/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Receptors, Serotonin; 0/Serotonin Antagonists; 0/Serotonin Receptor Agonists; 50-67-9/Serotonin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Dual Role of Toll-Like Receptors in Asthma and Chronic Obstructive Pulmonary Disease.
Next Document: Conus Venom Peptide Pharmacology.