Document Detail


Serotonin and blood pressure regulation.
MedLine Citation:
PMID:  22407614     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
5-Hydroxytryptamine (5-HT; serotonin) was discovered more than 60 years ago as a substance isolated from blood. The neural effects of 5-HT have been well investigated and understood, thanks in part to the pharmacological tools available to dissect the serotonergic system and the development of the frequently prescribed selective serotonin-reuptake inhibitors. By contrast, our understanding of the role of 5-HT in the control and modification of blood pressure pales in comparison. Here we focus on the role of 5-HT in systemic blood pressure control. This review provides an in-depth study of the function and pharmacology of 5-HT in those tissues that can modify blood pressure (blood, vasculature, heart, adrenal gland, kidney, brain), with a focus on the autonomic nervous system that includes mechanisms of action and pharmacology of 5-HT within each system. We compare the change in blood pressure produced in different species by short- and long-term administration of 5-HT or selective serotonin receptor agonists. To further our understanding of the mechanisms through which 5-HT modifies blood pressure, we also describe the blood pressure effects of commonly used drugs that modify the actions of 5-HT. The pharmacology and physiological actions of 5-HT in modifying blood pressure are important, given its involvement in circulatory shock, orthostatic hypotension, serotonin syndrome and hypertension.
Authors:
Stephanie W Watts; Shaun F Morrison; Robert Patrick Davis; Susan M Barman
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2012-03-08
Journal Detail:
Title:  Pharmacological reviews     Volume:  64     ISSN:  1521-0081     ISO Abbreviation:  Pharmacol. Rev.     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-03-16     Completed Date:  2012-07-16     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  0421737     Medline TA:  Pharmacol Rev     Country:  United States    
Other Details:
Languages:  eng     Pagination:  359-88     Citation Subset:  IM    
Affiliation:
Department of Pharmacology & Toxicology, Michigan State University, East Lansing, MI 48824-1317, USA. wattss@msu.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Pressure / physiology*
Humans
Hypertension / physiopathology
Hypotension, Orthostatic / physiopathology
Receptors, Serotonin / drug effects,  metabolism*
Serotonin / metabolism*
Serotonin Antagonists / pharmacology
Serotonin Receptor Agonists / pharmacology
Serotonin Syndrome / physiopathology
Shock / physiopathology
Species Specificity
Grant Support
ID/Acronym/Agency:
HL081115/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Receptors, Serotonin; 0/Serotonin Antagonists; 0/Serotonin Receptor Agonists; 50-67-9/Serotonin
Comments/Corrections

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