Document Detail


Serotonin 2A receptors in obsessive-compulsive disorder: a positron emission tomography study with [11C]MDL 100907.
MedLine Citation:
PMID:  21855857     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Serotonergic abnormalities are hypothesized to contribute to obsessive-compulsive disorder (OCD). This study used positron emission tomography with the radioligand [11C]MDL 100907 to examine whether the distribution of serotonin 2A (5-HT(2A)) receptors is altered in OCD.
METHODS: Nineteen OCD subjects, free of psychiatric medications and depression, and 19 matched healthy subjects underwent positron emission tomography scans following injection of [11C]MDL 100907. Total distribution volumes were derived by kinetic analysis using the arterial input function. Two measures of 5-HT(2A) availability were computed: the ratio at equilibrium of specifically bound radiotracer either to nondisplaceable radiotracer in tissue (BP(ND)) or to unmetabolized tracer in arterial plasma (BP(p)). Groups were compared using a region of interest (ROI) analysis and voxelwise analysis of spatially normalized parametric maps. ROIs included cortical (orbitofrontal, dorsolateral prefrontal, medial prefrontal, anterior cingulate, temporal, parietal, occipital, and insular cortex) and limbic (entorhinal cortex, parahippocampal gyrus, and medial temporal lobe) regions.
RESULTS: No significant group differences were observed in [11C]MDL 100907 BP(ND) or BP(p) in the ROIs or in the voxelwise analysis of BP(ND) maps. There was a significant correlation in the orbitofrontal cortex between [11C]MDL 100907 binding and age of onset, with earlier age of onset associated with higher binding.
CONCLUSIONS: Adults with OCD are not characterized as a group by major changes in 5-HT(2A) availability in cortical or limbic brain regions. Further research is warranted to examine potential differences in 5-HT(2A) availability between early- and late-onset OCD and to assess 5-HT(2A) function in relation to other neurotransmitter systems implicated in OCD.
Authors:
Helen Blair Simpson; Mark Slifstein; James Bender; Xiaoyan Xu; Elizabeth Hackett; Michael J Maher; Anissa Abi-Dargham
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biological psychiatry     Volume:  70     ISSN:  1873-2402     ISO Abbreviation:  Biol. Psychiatry     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-10-11     Completed Date:  2012-02-01     Revised Date:  2014-03-16    
Medline Journal Info:
Nlm Unique ID:  0213264     Medline TA:  Biol Psychiatry     Country:  United States    
Other Details:
Languages:  eng     Pagination:  897-904     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Age of Onset
Female
Fluorobenzenes / diagnostic use*
Humans
Image Processing, Computer-Assisted
Isotope Labeling
Limbic System / radionuclide imaging
Magnetic Resonance Imaging
Male
Middle Aged
Obsessive-Compulsive Disorder / metabolism,  radionuclide imaging*
Piperidines / diagnostic use*
Positron-Emission Tomography
Psychiatric Status Rating Scales
Radiopharmaceuticals / diagnostic use*
Receptor, Serotonin, 5-HT2A / metabolism,  physiology*
Serotonin Antagonists / diagnostic use*
Young Adult
Grant Support
ID/Acronym/Agency:
R01 MH073915/MH/NIMH NIH HHS; R01 MH073915/MH/NIMH NIH HHS
Chemical
Reg. No./Substance:
0/Fluorobenzenes; 0/Piperidines; 0/Radiopharmaceuticals; 0/Receptor, Serotonin, 5-HT2A; 0/Serotonin Antagonists; 139290-65-6/MDL 100907
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