Document Detail

Serotonin 1A-receptor activation suppresses respiratory apneusis in the cat.
MedLine Citation:
PMID:  8084536     Owner:  NLM     Status:  MEDLINE    
Malfunction of inhibitory synaptic processes in the brainstem result in abnormal prolonged inspiration (apneusis). Since we previously found that the serotonin (5-hydroxytryptamine; 5-HT) 5-HT1A receptor agonist 8-hydroxy-dipropylaminotetralin (8-OH-DPAT) shortens inspiratory discharges, we tested its ability to suppress apneusis. We recorded phrenic nerve activity and the membrane potential of medullary expiratory (E-2) and postinspiratory (PI) neurons in 14 anaesthetized, paralyzed, artificially ventilated cats. Systemic hypoxia or i.v. injection of pentobarbital sodium or the N-methyl-D-aspartate (NMDA) receptor blocker ketamine induced apneustic phrenic nerve discharges, delayed depolarization to threshold of E-2 neurons and prolonged hyperpolarization in PI neurons. 8-OH-DPAT (10-40 micrograms/kg i.v.) produced partial to complete restoration of normal phrenic nerve discharges and membrane potential.
P M Lalley; A M Bischoff; D W Richter
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Neuroscience letters     Volume:  172     ISSN:  0304-3940     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  1994 May 
Date Detail:
Created Date:  1994-10-11     Completed Date:  1994-10-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  59-62     Citation Subset:  IM    
II. Institute of Physiology, University of Goettingen, FRG.
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MeSH Terms
8-Hydroxy-2-(di-n-propylamino)tetralin / administration & dosage,  pharmacology*
Anoxia / physiopathology
Injections, Intraventricular
Ketamine / antagonists & inhibitors,  pharmacology
Membrane Potentials / drug effects
Pentobarbital / antagonists & inhibitors,  pharmacology
Phrenic Nerve / drug effects,  physiopathology
Receptors, Serotonin / drug effects,  metabolism*
Respiratory Mechanics / drug effects*
Synapses / drug effects
Reg. No./Substance:
0/Receptors, Serotonin; 6740-88-1/Ketamine; 76-74-4/Pentobarbital; 78950-78-4/8-Hydroxy-2-(di-n-propylamino)tetralin

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