Document Detail

Serotonergic modulation of ingestive behavior in pigeons.
MedLine Citation:
PMID:  2524843     Owner:  NLM     Status:  MEDLINE    
The effects of peripheral administration of the serotonin agonist zimeldine and the serotonin antagonist cyproheptadine on food and water consumption were evaluated in domestic pigeons. Injections of zimeldine reduced the amount of feeding and drinking dose-dependently in 24-hr fasted animals. Administration of cyproheptadine enhanced food and water consumption dose-dependently up to a dose of 160 micrograms per 100 g body weight in nondeprived pigeons. Higher doses reduced ingestion probably due to a general behavioral depression. The effect of zimeldine was antagonized by cyproheptadine. It is concluded that, as in mammals, serotonin participates as an inhibitor in the regulation of feeding in birds. Contrary to the situation in mammals it has no activating effect on drinking but leads to a reduction of water consumption in pigeons.
O Güntürkün; A Grothues; A Hautkappe; F Visé; N Wawrzyniak; U Zwilling
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pharmacology, biochemistry, and behavior     Volume:  32     ISSN:  0091-3057     ISO Abbreviation:  Pharmacol. Biochem. Behav.     Publication Date:  1989 Feb 
Date Detail:
Created Date:  1989-07-12     Completed Date:  1989-07-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0367050     Medline TA:  Pharmacol Biochem Behav     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  415-20     Citation Subset:  IM    
FB Psychologie, Universität Konstanz, FRG.
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MeSH Terms
Cyproheptadine / pharmacology
Drinking Behavior / physiology*
Drug Interactions
Feeding Behavior / physiology*
Pimozide / pharmacology
Serotonin / physiology*
Time Factors
Zimeldine / pharmacology
Reg. No./Substance:
129-03-3/Cyproheptadine; 2062-78-4/Pimozide; 50-67-9/Serotonin; 56775-88-3/Zimeldine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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