| Serotonergic mechanisms in hypertension. | |
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MedLine Citation:
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PMID: 8138327 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Serotonin and abnormal serotonergic activity (both central and peripheral) may play a role in pathogenesis of essential hypertension. Serotonin acts chiefly via three types of receptors namely S1, S2 and S3 serotonergic receptors. Besides being vasoactive, it has some inotropic and chronotropic properties and also affects blood rheology. It has stimulating effect on renin and aldosterone secretion. The action of other vasoactive substances like norepinephrine and angiotensin II are amplified. All these physiological effects of serotonin strongly support the hypothesis that it may be involved in hypertension. The advent of serotonin antagonists in lowering blood pressure has further substantiated this hypothesis. |
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Authors:
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M Chandra; N Chandra |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: International journal of cardiology Volume: 42 ISSN: 0167-5273 ISO Abbreviation: Int. J. Cardiol. Publication Date: 1993 Dec |
Date Detail:
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Created Date: 1994-04-26 Completed Date: 1994-04-26 Revised Date: 2006-07-12 |
Medline Journal Info:
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Nlm Unique ID: 8200291 Medline TA: Int J Cardiol Country: IRELAND |
Other Details:
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Languages: eng Pagination: 189-96 Citation Subset: IM |
Affiliation:
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Department of Medicine, King George's Medical College, Lucknow, India. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Humans Hypertension / physiopathology* Receptors, Serotonin / physiology Serotonin / physiology* |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Serotonin; 50-67-9/Serotonin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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